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Medications

DIN (Drug Identification Number)

02274248 CO GLIMEPIRIDE 1 MG TABLET 02274256 CO GLIMEPIRIDE 2 MG TABLET 02274272 CO GLIMEPIRIDE 4 MG TABLET

Glimepiride belongs to a group of medications known as oral hypoglycemics . It is used to control blood sugar for people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood sugar well enough on their own. Glimepiride increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently.

Glimepiride may be used in combination with metformin or insulin when diet and exercise and the use of these medications on their own do not provide adequate control of blood sugar.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

CO-Glimepiride is no longer being manufactured for sale in Canada. For brands that may still be available, search under glimepiride. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

The usual starting dose is 1 mg once daily to be taken with breakfast or the first main meal. After reaching a dose of 2 mg, further increases should be done in increments of no more than 1 mg at one-week to 2-week intervals, based on the response. The usual maintenance adult dose ranges from 1 mg to 4 mg once daily to be taken with breakfast or the first main meal of the day. The maximum daily dose is 8 mg.

Gilmepiride tablets should be swallowed whole with approximately ½ glass of liquid. Do not chew or crush this medication.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking this medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not take glimepiride if you:

are allergic to glimepiride or any ingredients of the medication

are pregnant or breast-feeding

have type 1 diabetes (i. e. insulin-dependent diabetes)

have diabetic ketoacidosis, with or without coma

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision

fever

general feeling of illness

increased skin sensitivity or skin rashes following sun exposure

signs of bleeding (e. g. bleeding gums, blood in the urine, dark tarry stools, easy bruising, nosebleeds, vomiting blood)

signs of high blood sugar ( hyperglycemia ; e. g, dry mouth, dry skin, flushing, frequent urination, loss of appetite, thirst, tiredness, trouble breathing)

signs of low blood sugar ( hypoglycemia ; e. g. blurred vision, dizziness, fatigue, headache, numbness or tingling of the mouth, pale colour, rapid heartbeat, shakiness, sudden hunger, sweating or confusion, weakness)

signs of liver damage (e. g. abdominal pain, dark urine, fatigue, fever, loss of appetite, yellow skin or eyes)

skin redness, itching, or rash

sore throat

swelling of the hands or feet

unusual tiredness or weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain

signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

signs of a serious allergic reaction (e. g. abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

signs of very low blood sugar (e. g. convulsions or seizures, loss of consciousness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergy: Some people who are allergic to sulfonamide antibiotics or other similar diabetes medications also experience allergic reactions to glimepiride. Before you take glimepiride inform your doctor about any previous adverse reactions you have had to medications, especially to antibiotics or other diabetes medications. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.

Drowsiness/reduced alertness: Due to the effect of glimepiride on blood sugar, it may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how this medication affects you.

Hypoglycemia (low blood sugar): Hypoglycemia is a condition in which blood sugar levels are abnormally low. Symptoms of hypoglycemia include:

dizziness

drowsiness

headache

lack of energy

nervousness

numbness or tingling of the mouth

shakiness

sweating

weakness

People with more severe hypoglycemia can experience blurred vision, confusion, and an inability to concentrate. If left untreated, severe hypoglycemia can lead to convulsions (seizures) and unconsciousness within minutes. People who are more likely to become hypoglycemic include seniors, people with reduced liver or kidney function, people who are malnourished, or people taking beta-blockers or other medications that lower blood sugar. Low blood sugar is more likely to occur when food intake is inadequate, or after strenuous or prolonged physical exercise. Blood sugar should be monitored regularly and an emergency source of sugar (e. g. a sugar packet, orange juice, or hard candy) and glucagon kit should be made available in case the need arises to increase blood sugar levels.

Loss of blood sugar control: People on glimepiride may experience loss of blood sugar control during illness or stressful situations such as fever, infection, trauma, or surgery. Under these conditions, your doctor may consider stopping the medication and prescribing insulin until your blood sugar is controlled and within target levels. For some people, their doctor may prescribe insulin or metformin in combination with glimepiride to control blood sugar.

Proper diet: Glimepiride is a treatment to be used in combination with a proper diet. Glimepiride is not as a substitute for a proper diet.

Worsening of condition: Over time, glimepiride may become less effective because of the worsening of diabetes. Talk to your doctor if glimepiride no longer controls your blood glucose to target levels. Your doctor may ask you to stop this medication, or continue this medication and take an additional antidiabetic medication to help control your blood sugar.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if glimepiride passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: The side effects of this medication may be more noticeable in seniors. People who are over 65 years old should discuss with their doctor how this medication may affect them and whether any special monitoring is needed.

There may be an interaction between glimepiride and any of the following:

acetylsalicylic acid (ASA)

alcohol

amiodarone

anabolic steroids

angiotensin receptor blockers (ARBs; e. g. candasartan, irbesartan, losartan)

aprepitant

"azole" antifungals (e. g. itraconazole, ketoconazole, voriconazole)

barbiturates (e. g. phenobarbital, secobarbital)

beta-blockers (e. g. atenolol, metoprolol)

bosentan

buserelin

carbamazepine

capecitabine

chloramphenicol

clarithromycin

clonidine

inhaled corticosteroids (e. g. budesonide, ciclesonide, fluticasone)

oral corticosteroids (e. g. dexamethasone, hydrocortisone, prednisone)

corticosteroids (e. g. budesonide, hydrocortisone, prednisone)

cyclophosphamide

cyclosporine

dabrafenib

other diabetes medications (e. g. chlorpropamide, glipizide, glyburide, insulin, metformin, nateglinide, rosiglitazone)

diazoxide

disopyramide

diuretics (e. g. furosemide, hydrochlorothiazide, acetazolamide)

epinephrine

estrogens (e. g. conjugated estrogens)

fibrates (e. g. fenofibrate, gemfibrozil)

fluorouracil

fluvastatin

glucagon

goserelin

guanethidine

H2-receptor antagonists (e. g. ranitidine)

HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e. g. delaviridine, efavirenz, etravirine, nevirapine)

laxatives (after prolonged use)

leflunomide

monoamine oxidase inhibitors (MAOIs; e. g. moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)

milk thistle

nilotinib

nonsteroidal anti-inflammatory drugs (e. g. ibuprofen, naproxen)

omeprazole

peginterferon Alfa-2b

phenytoin

phenothiazines (e. g. chlorpromazine)

phenylbutazone

porfimer

primidone

probenecid

progestogens (e. g. medroxyprogesterone)

propranolol

pyrimethamine

quinine

quinolone antibiotics (e. g. ciprofloxacin, norfloxacin, ofloxacin)

reserpine

rifampin

salicylates (e. g. ASA, salsalate)

selective serotonin reuptake inhibitors (SSRIs; e. g. citalopram, duloxetine, fluoxetine, paroxetine, sertraline)

somatropin

sorafenib

sulfonamides (e. g.,sulfadiazine, sulfamethoxazole, sulfasoxazole)

sympathometics (cough, cold or allergy medication)

testosterone

tetracyclines (e. g. tetracycline, minocycline)

thyroid hormones (e. g. levothyroxine)

ticagrelor

tolbutamide

tricyclic antidepressasnts (e. g. amitriptyline, clomipramine, desipramine, trimipramine)

trimethoprim

warfarin

zafirlukast

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material © 1996-2016 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Caffeine uses, side effects, interactions and warnings, coffein

CAFFEINE

Overview

Caffeine is a chemical found in coffee, tea, cola, guarana, mate, and other products.

Caffeine is most commonly used to improve mental alertness, but it has many other uses. Caffeine is used by mouth or rectally in combination with painkillers (such as aspirin and acetaminophen ) and a chemical called ergotamine for treating migraine headaches. It is also used with painkillers for simple headaches and preventing and treating headaches after epidural anesthesia.

Some people use caffeine for asthma. gallbladder disease, attention deficit-hyperactivity disorder (ADHD ), shortness of breath in newborns, and low blood pressure. Caffeine is also used for weight loss and type 2 diabetes. Very high doses are used, often in combination with ephedrine. as an alternative to illegal stimulants.

Caffeine is one of the most commonly used stimulants among athletes. Taking caffeine, within limits, is allowed by the National Collegiate Athletic Association (NCAA). Urine concentrations over 15 mcg/mL are prohibited. It takes most people about 8 cups of coffee providing 100 mg/cup to reach this urine concentration.

Caffeine creams are applied to the skin to reduce redness and itching in dermatitis .

Healthcare providers sometimes give caffeine intravenously (by IV) for headache after epidural anesthesia, breathing problems in newborns, and to increase urine flow.

In foods, caffeine is used as an ingredient in soft drinks, energy drinks, and other beverages.

People with voice disorders, singers, and other voice professionals are often advised against using caffeine. However, until recently, this recommendation was based only on hearsay. Now developing research seems to indicate that caffeine may actually harm voice quality. But further study is necessary to confirm these early findings.

How does it work?

Caffeine works by stimulating the central nervous system (CNS), heart, muscles, and the centers that control blood pressure. Caffeine can raise blood pressure, but might not have this effect in people who use it all the time. Caffeine can also act like a ôwater pillö that increases urine flow. But again, it may not have this effect in people who use caffeine regularly. Also, drinking caffeine during moderate exercise is not likely to cause dehydration .

Uses

Effective for

Migraine headache. Taking caffeine by mouth together with painkillers such aspirin and acetaminophen is effective for treating migraines. Caffeine is an FDA-approved product for use with painkillers for treating migraine headaches.

Headache following surgery. Using caffeine by mouth or intravenously (by IV) is effective for preventing headaches following surgery. Caffeine is an FDA-approved product for this use in people who regularly consume products that contain caffeine.

Tension headache. Taking caffeine by mouth in combination with painkillers is effective for treating tension headaches.

Likely Effective for

Mental alertness. Research suggests that drinking caffeinated beverages throughout the day keeps the mind alert. Combining caffeine with glucose as an ôenergy drinkö seems to improve mental performance better than either caffeine or glucose alone.

Possibly Effective for

Asthma. Caffeine appears to improve airway function for up to 4 hours in people with asthma.

Athletic performance. Taking caffeine seems to increase physical strength and endurance and might delay exhaustion. It might also reduce feelings of exertion and improve performance during activities such as cycling, running, playing soccer, and golfing. However, caffeine does not seem to improve performance during short-term, high-intensity exercise such as sprinting and lifting.

Diabetes. Drinking beverages that contain caffeine is linked with a lower risk of developing type 2 diabetes. It appears that the more caffeine that is consumed, the lower the risk. Although caffeine might help prevent type 2 diabetes, it might not be effective in treating type 2 diabetes. Research on the effects of caffeine in people with type 1 diabetes is inconsistent. Some research shows benefit, while other research does not.

Gallbladder disease. Drinking beverages that provide at least 400 mg of caffeine daily seems to reduce the risk of developing gallstone disease. The effect seems to be dose-dependent. Taking 800 mg of caffeine daily seems to work best.

Low blood pressure after eating. Drinking caffeinated beverages seems to increase blood pressure in older people with low blood pressure after eating.

Memory. Taking 200 mg of caffeine by mouth daily seems to improve memory in some people with outgoing personalities and college students.

Breathing problems in infants. Caffeine given by mouth or intravenously (by IV) appears to improve breathing in infants born too early. It seems to reduce the number of episodes of shortness of breath by at least 50% over 7-10 days of treatment. However, caffeine does not seem to reduce the risk of premature infants developing breathing problems.

Pain. Research suggests that taking caffeine together with painkillers can reduce pain.

Parkinsonĺs disease. Some research suggests that people who drink caffeinated beverages have a decreased risk of Parkinsonĺs disease. However, this reduced risk is not observed in people who smoke cigarettes.

Headache after epidural anesthesia. Taking caffeine by mouth or intravenously (by IV) seems to help prevent headache after epidural anesthesia

Weight loss. Taking caffeine in combination with ephedrine seems to help reduce weight, short-term. Taking 192 mg of caffeine in combination with 90 mg of ephedra daily for 6 months seems to cause a modest weight reduction (5.3 kg or 11.66 pounds) in overweight people. This combination, along with limiting fat intake to 30 percent of calories and moderate exercise, also seems to reduce body fat, decrease ôbadö low-density lipoprotein (LDL) cholesterol, and increase ôgoodö high-density lipoprotein (HDL) cholesterol. However, there can be unwanted side effects. Even in carefully screened and monitored otherwise healthy adults, caffeine/ephedra combinations can cause changes in blood pressure and heart rate.

Possibly Ineffective for

Attention deficit-hyperactivity disorder (ADHD). Most research suggests that caffeine does not reduce ADHD symptoms in children. The use of caffeine in adolescents and adults with ADHD has not been studied.

Insufficient Evidence for

Depression. Some research suggests that caffeine intake is linked with an increased occurrence of depression symptoms in children. However, other research suggests that caffeinated coffee intake is linked to a decreased occurrence of depression in adults.

Low levels of oxygen in the blood caused by exercise. Early research shows that taking caffeine may improve breathing during exercise, but does not affect blood levels of oxygen in athletes with low blood oxygen levels during exercise

Hepatitis C. Research suggests that higher intake of caffeine from coffee is linked to reduced liver scarring in people with hepatitis C.

Headaches while sleeping. Some early evidence suggests that drinking a cup of coffee before bed or upon waking up might help alleviate pain associated with headaches that occur during sleep.

Cramping due to narrowed arteries (intermittent claudication). Taking a single 6 mg dose of caffeine by mouth seems to improve walking and muscle strength in people with aching and cramping due to narrowed or blocked arteries.

Liver cirrhosis. Research suggests that drinking coffee might reduce the risk for liver cirrhosis. However, it is unclear if this effect is due to caffeine or other components of coffee.

Muscle soreness during exercise. Evidence on the effect of caffeine for muscle soreness during exercise is inconsistent. It seems that taking moderate doses of caffeine (10 mg/kg) can reduce muscle pain during exercise, while lower doses may not have this effect.

Obsessive-compulsive disorder (OCD). Early research shows that adding caffeine to conventional therapy seems to decrease the severity of OCD symptoms.

Stoke. Research shows that increased caffeinated or decaffeinated coffee intake is linked to a decreased risk of stroke in women. However, it is not clear if the effect is due to caffeine.

Skin irritation, redness, and itching.

Overdose.

Other conditions.

More evidence is needed to rate caffeine for these uses.

Side Effects

Caffeine is LIKELY SAFE for most adults when used appropriately.

Caffeine is POSSIBLY UNSAFE when taken by mouth for a long time or in fairly high doses. Caffeine can cause insomnia, nervousness and restlessness, stomach irritation, nausea and vomiting, increased heart rate and respiration, and other side effects. Caffeine can make sleep disorders in patients with acquired immunodeficiency syndrome (AIDS) worse. Larger doses might cause headache, anxiety, agitation, chest pain, and ringing in the ears.

Caffeine is LIKELY UNSAFE when taken by mouth in very high doses as it can cause irregular heartbeats and even death.

Special Precautions & Warnings:

Children . Caffeine is POSSIBLY SAFE when taken appropriately by mouth or intravenously (by IV), as well as when used in amounts commonly found in foods and beverages.

Pregnancy and breast-feeding . Caffeine is POSSIBLY SAFE in pregnant or breast-feeding women when used daily amounts of less than 200 mg. This is about the amount in 1-2 cups of coffee. Consuming larger amounts during pregnancy or when breast-feeding is POSSIBLY UNSAFE . When consumed in larger amounts during pregnancy, caffeine might increase the chance of miscarriage and other problems. Also, caffeine can pass into breast milk, so nursing mothers should closely monitor caffeine intake to make sure it is on the low side. High intake of caffeine by nursing mothers can cause sleep disturbances, irritability, and increased bowel activity in breast-fed infants.

Anxiety disorders . Caffeine might make these conditions worse. Use with care.

Bipolar disorder . Too much caffeine might make this condition worse. In one case, a 36-year-old man with controlled bipolar disorder was hospitalized with symptoms of mania after drinking several cans of an energy drink containing caffeine, taurine, inositol, and other ingredients (Red Bull Energy Drink) over a period of 4 days. Use caffeine with care and in low amounts if you have bipolar disorder.

Bleeding disorders . There is concern that caffeine might aggravate bleeding disorders. Use caffeine with care if you have a bleeding disorder.

Heart conditions . Caffeine can cause irregular heartbeat in sensitive people. Use caffeine with caution.

Diabetes . Some research suggests that caffeine may affect the way the body uses sugar and might worsen diabetes. However, the effect of caffeinated beverages and supplements has not been studied. If you have diabetes, use caffeine with caution.

Diarrhea . Caffeine, especially when taken in large amounts, can worsen diarrhea.

Epilepsy . People with epilepsy should avoid using caffeine in high doses. Low doses of caffeine should be used cautiously.

Glaucoma . Caffeine increases the pressure inside the eye. The increase occurs within 30 minutes and lasts for at least 90 minutes after drinking caffeinated beverages.

High blood pressure . Consuming caffeine might increase blood pressure in people with high blood pressure. However, this effect might be less in people who use caffeine regularly.

Irritable bowel syndrome (IBS) . Caffeine, especially when taken in large amounts, can worsen diarrhea and might worsen symptoms of IBS.

Weak bones (osteoporosis) . Caffeine can increase the amount of calcium that is flushed out in the urine. If you have osteoporosis or low bone density, caffeine should be limited to less than 300 mg per day (approximately 2-3 cups of coffee). It is also a good idea to get extra calcium to make up for the amount that may be lost in the urine. Older women with an inherited disorder that affects the way vitamin D is used should use caffeine with caution. Vitamin D works with calcium to build bones.

Interactions

Major Interaction: Do not take this combination

Ephedrine interacts with CAFFEINE

Stimulant drugs speed up the nervous system. Caffeine and ephedrine are both stimulant drugs. Taking caffeine along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.

Moderate Interaction: Be cautious with this combination

Adenosine (Adenocard) interacts with CAFFEINE

Caffeine might block the effects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test.

Antibiotics (Quinolone antibiotics) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with caffeine can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.

Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).

Cimetidine (Tagamet) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with caffeine might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.

Clozapine (Clozaril) interacts with CAFFEINE

The body breaks down clozapine (Clozaril) to get rid of it. Caffeine seems to decrease how quickly the body breaks down clozapine (Clozaril). Taking caffeine along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).

Dipyridamole (Persantine) interacts with CAFFEINE

Caffeine might block the affects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test.

Disulfiram (Antabuse) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking caffeine along with disulfiram (Antabuse) might increase the effects and side effects of caffeine including jitteriness, hyperactivity, irritability, and others.

Estrogens interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking caffeine along with estrogens might cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogens limit your caffeine intake.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Fluvoxamine (Luvox) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking caffeine along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine.

Lithium interacts with CAFFEINE

You body naturally gets rid of lithium. Caffeine can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping caffeine too quickly can increase the side effects of lithium.

Medications for depression (MAOIs) interacts with CAFFEINE

Caffeine can stimulate the body. Some medications used for depression can also stimulate the body. Taking caffeine along with some medications for depression might cause serious side effects including fast heartbeat, high blood pressure, nervousness, and others.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with CAFFEINE

Caffeine might slow blood clotting. Taking caffeine along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Pentobarbital (Nembutal) interacts with CAFFEINE

The stimulant effects of caffeine can block the sleep-producing effects of pentobarbital.

Phenylpropanolamine interacts with CAFFEINE

Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking caffeine along with phenylpropanolamine might cause too much stimulation and increase heartbeat, blood pressure, and cause nervousness.

Riluzole (Rilutek) interacts with CAFFEINE

The body breaks down riluzole (Rilutek) to get rid of it. Taking caffeine along with riluzole (Rilutek) might decrease how fast the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole (Rilutek).

Stimulant drugs interacts with CAFFEINE

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heart rate. Caffeine might also speed up the nervous system. Taking caffeine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Theophylline interacts with CAFFEINE

Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking theophylline along with caffeine might increase the effects and side effects of theophylline.

Verapamil (Calan, Covera, Isoptin, Verelan) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Taking caffeine along with verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for caffeine including jitteriness, headache, and an increased heartbeat.

Minor Interaction: Be watchful with this combination

Alcohol interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking caffeine along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.

Birth control pills (Contraceptive drugs) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking caffeine along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Fluconazole (Diflucan) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine. Taking caffeine along with fluconazole (Diflucan) might cause caffeine to stay in to body too long and increase the risk of side effects such as nervousness, anxiety, and insomnia.

Medications for diabetes (Antidiabetes drugs) interacts with CAFFEINE

Caffeine might increase blood sugar. Diabetes medications are used to lower blood sugar. Taking some medications for diabetes along with caffeine might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Mexiletine (Mexitil) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with caffeine might increase the effects and side effects of caffeine.

Terbinafine (Lamisil) interacts with CAFFEINE

The body breaks down caffeine to get rid of it. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine. Taking caffeine along with terbinafine (Lamisil) can increase the risk of caffeine side effects including jitteriness, headache, increased heartbeat, and other effects.

Dosing

The following doses have been studied in scientific research:

BY MOUTH .

For headache or improving mental alertness: 250 mg per day.

For tiredness: 150-600 mg.

For improving athletic performance: 2-10 mg/kg or more has been used. However, doses in excess of 800 mg per day can result in urine levels greater than the 15 mcg/mL allowed by the National Collegiate Athletic Association.

For weight loss: the ephedrine/caffeine combination products are commonly dosed 20 mg/200 mg three times per day.

For headache after epidural anesthesia: 300 mg.

For preventing gallstone disease: intake of 400 mg or more of caffeine per day.

For preventing Parkinsonĺs disease: men drinking 421-2716 mg of total caffeine daily have the lowest risk of developing Parkinson's disease. when compared to other men. However, men who drink as little as 124-208 mg of caffeine daily also have a significantly lower chance of developing Parkinson's disease. In women, moderate caffeine intake per day (1-3 cups of coffee per day) seems to be best.

One cup of brewed coffee provides from 95-200 mg of caffeine. An 8-ounce serving of black tea provides from 40-120 mg of caffeine. An 8-ounce serving of green tea provides 15-60 mg of caffeine. Soft drinks such as cola provide from 20-80 mg of caffeine per 12 ounce serving. Sports or energy drinks typically provide from 48-300 mg of caffeine per serving.

INTRAVENOUS .

Caffeine is given intravenously (by IV) by healthcare providers for breathing problems in infants and for headache after epidural anesthesia.

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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Drugs and medications, normatens

Atenolol 50 / 100mg

Composition Normaten Tablets 50mg. Each tablet contains Atenolol 50mg and Titanium dioxide 0.5% as colourant. Normaten Tablets 100mg. Each tablet contains Atenolol 100mg. Contains Sunset Yellow 0.34% and Titanium Dioxide 1.00% as colourants.

Properties Atenolol is a hydrophilic β 1 - adrenoceptor blocking drug with general properties similar to those of propranolol. It reduces cardiac activity by diminishing or preventing sympathetic β-adrenoceptor stimulation. It reduces the rate and force of contraction of the heart and decreases the rate of conduction of impulses through the conducting system. Its principal effect is to reduce the response of the heart to stress and exercise and it reduces blood pressure in patients with hypertension. Atenolol is classified as cardioselective and is reported to lack intrinsic sympathomimetic activity and membrane stabilising properties.

Atenolol is incompletely absorbed from the gastrointestinal tract and is not significantly metabolised. It is excreted in the urine and its biological half-life is longer than would be anticipated from its plasma half-life of about 6 - 7 hours. Atenolol diffuses across the placenta and is excreted in breast milk. Only small amounts are reported to cross the blood brain barrier, and it is only about 5 % bound to plasma protein.

Indications Normaten is indicated for the control of hypertension and management of angina pectoris. It is also used as oral maintenance therapy for cardiac dysrhythmias after the acute attacks has been controlled by intravenous therapy and for long-term prophylaxis of myocardial infarction after recovery.

Dosage and Administration In adult and children over 12 years :

Hypertension . 50 to 100mg daily as a single dose. The effects will be fully established after 1 to 2 weeks. A further reduction in blood pressure may be achieved by combining Atenolol with other antihypertensive agents.

Angina . 50mg twice daily or 100mg daily once. It is unlikely that the higher dose would be additionally beneficial.

Dysrhythmias . Initially controlled intravenously. Oral maintenance dosage of 50 - 100mg daily, given as a single dose.

Myocardial infarction . In suitable patients, Initially controlled intravenously, followed by 50mg Normaten orally, 15 minutes after the intravenous dose, provided no adverse effects occur. This should be followed by a further 50mg orally 12 hours later, then 24 hours later by 100mg orally to be given once daily for up to 10 days. If bradycardia and/or hypotension, or other adverse effects occur, requiring treatment, Normaten should be discontinued.

The elderly. Dosage requirements may be reduced, especially in patients with impaired renal function.

Children. There is no paediatric experience with Atenolol. Atenolol is not recommended for use in children under 12 years of age.

Dosage should be adjusted in patients with severe impairment of renal function as Atenolol is excreted via kidneys.

>35ml/min/1.73 m 2

no adjustment required

15 - 35ml/min/1.73 m 2

50mg daily or 100mg once every two days

<15ml/min/1.73 m 2

50mg on alternate days or 100mg once every four days

Contraindications It is contraindicated in patients with bronchospasm or obstructive airways disease, metabolic acidosis, sinus bradycardia, or partial heart block (second or third degree heart block). It should not be used in patients with cardiogenic shock and in overt heart failure.

Precautions Atenolol should not be given to patients with phaeochromocytoma without concomitant α-adrenoceptor blocking therapy. Use with caution in pregnancy, during breast feeding, in patients with inadequate cardiac function, diabetes mellitus or hyperthyroidism.

Avoid abrupt withdrawal especially in patients with coronary artery disease, since it may exacerbate angina or precipitate myocardial infarction. Reduce dose may be required in patients with renal failure.

Special care should be taken with patients whose cardiac reserve is poor. β-adrenoreceptor blockers should be avoided in overt heart failure. However, they may be used in patients whose signs of failure have been controlled.

One of the pharmacological actions of Normaten is to reduce heart rate. In rare instances when symptoms may be attributable to the slow heart rate, the dose may be reduced. Normaten modifies the tachycardia of hypoglycaemia.

Although cardioselective (β 1 ) β-blockers may have less effect on lung function than non-selective β-blockers, as with all β-blockers, these should be avoided in patients with reversible obstructive airways disease, unless there are compelling clinical reasons for their use. Where such reason exist, Normaten may be used with caution. Occasionally, some increase in airway resistance may occur in asthmatic patients, however, and this may usually be reversed by commonly used of bronchodilators such as salbutamol or isoprenaline.

In patients suffering from ischaemic heart disease, as with other β-blocking agents, treatment should not be discontinued abruptly.

Anaesthesia. Care should be taken when using anaesthetic agents with Normaten. The anaesthetist should be informed and the choice of anaesthetic should be the agent with as little negative inotropic activity as possible.

See also section under Drug Interactions below.

Drug Interactions Normaten may enhance the effects of other myocardial depressant including anti-arrhythmics such as quinidine, procainamide, lignocaine, phenytoin and verapamil. The effects of Atenolol may be diminished by isoprenaline and may be enhanced by guanethidine, bethanidine, reserpine, and diuretics. Its peripheral vasoconstrictor effects may be enhanced by noradrenaline and adrenaline.

Caution should be exercised when transferring patients from clonidine to β-adrenoreceptor blocking drugs. If β-adrenoreceptor blocking drugs and clonidine are given concurrently, clonidine should riot be discontinued until several days after the withdrawal of the β-adrenoreceptor blocking drugs (see also prescribing information on clonidine)

Care should be exercised in prescribing β-adrenoreceptor blocking drug with Class 1 antidysrhythmic agents such as disopyramide.

β-adrenoreceptor blocking drugs should be used with caution in combination with verapamil in patients with impaired ventricular function. The combination should not be given to patients with conduction abnormalities. Neither drug should be administered intravenously with 48 hours of discontinuing the other.

Side Effects Atenolol shares the toxic potentials of β-adrenergic blocking agents. In therapeutic dosage, it is well tolerated and has low incidence of adverse effects.

Cardiovascular Effects : Potentially serious adverse cardiovascular effects of atenolol include bradycardia; profound hypotension; second of third-degree atrioventricular (AV) block; and precipitation of severe congestive heart failure (CHF), which is likely to occur in patients with pre-existing left ventricular dysfunction. Other adverse cardiovascular effects include coldness of the extremities and postural hypotension.

Central Nervous System Effects : Dizziness, fatigue, and mental depression are the most common CNS effects of atenolol. Less common effects are lethargy, drowsiness, unusual dreams, light-headedness and vertigo. Other effects that may occur include visual disturbances, hallucinations, disorientation, short-term memory impairment, emotional lability, catatonia and impaired performance on neuropsychometric tests.

Gastrointestinal Effects : Adverse GI reactions include diarrhoea, nausea and vomiting.

Other Adverse Effects : The possibility of other adverse effects associated with other β-adrenergic blocking agents that may occur include haematologic reactions (eg. agranulocytosis, nonthrombocytopenic or thrombocytopenic purpura); allergic reactions characterised by fever, sore throat laryngospasm, and respiratory distress; reversible alopecia; Peyronie's disease; Raynaud's phenomenon; erythematous rash; and impotence.

Overdosage and Treatment In the event of severe overdosage, hospital admission is strongly advised. Symptoms of overdosage may include severe reactions of the side effects. If the overdosage is recent, stomach should be emptied by gastric lavage. Severe bradycardia and hypotension may response to atropine 1-2mg intravenously. Where response is inadequate, a bolus dose of 5-10mg glucagon may be given intravenously, followed if necessary by an I. V. infusion of glucagon 1-5 mg/hour depending to response. The rate of infusion should be reduced as the patient improves. Dobutamine or isoprenaline have also been used in the management of hypotension. I. V. aminophylline, or inhaled or I. V. salbutamol, may be of benefit where bronchospasm occurs. Other supportive and symptomatic treatment should be given.

Shelf-life 4 years from the date of manufacture.

Presentation Normaten Tablets 50mg. White, round, coated tablets in 28's blister calendar packs of 14's.

Normaten Tablets 100mg. Orange, round, coated tablets in 28's blister packs of 7's.

Storage Protect from light and moisture. Store below 30?C.

Esotac-40; capsule, stride organics pvt ltd, esotac

ESOTAC-40 - Capsule, Stride Organics Pvt Ltd.

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Gyne-lotrimin vaginal, gyne-lotrimin

Gyne-Lotrimin vaginal

GENERIC NAME(S): CLOTRIMAZOLE

Uses

This medication is used to treat vaginal yeast infections. Clotrimazole reduces vaginal burning. itching. and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection. The vaginal product comes in 2 forms (a vaginal cream or tablet). Some products come with a skin cream to be applied to the area around the outside of the vagina .

Ask your doctor before using this medication for self-treatment if this is your first vaginal infection. This medication only works for vaginal fungal infections. You may have a different type of infection (such as bacterial vaginosis ) and may need a different medication.

If you have fever, chills, flu - like symptoms, stomach /abdominal pain. or a bad-smelling vaginal discharge. do not use this medication. Contact your doctor right away because these may be signs of a more serious infection.

How to use Gyne-Lotrimin vaginal

If you are using the over-the-counter product to self-treat, read all directions on the product package before using this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, use it as directed.

Read the Patient Information Leaflet available with this product. Consult your doctor or pharmacist if you have any questions.

This product is for vaginal use only. Wash your hands before and after use. Avoid contact of this product with your eyes. If it gets into your eyes. wash them right away with plenty of water. Call your doctor if eye irritation persists.

Dosage is based on your medical condition and response to treatment. Use the medication usually once daily at bedtime for 1 to 7 nights depending on the product used, or as directed by your doctor.

If using the vaginal cream, follow the package instructions on how to fill/use the applicator with the cream. Lie on your back with your knees toward your chest. Insert one applicator filled with cream into the vagina as far as it will comfortably go. Slowly press the plunger of the applicator in to apply the cream. Make sure to insert the correct cream for use inside the vagina, not the skin cream for use on the outer genital area (vulva).

If using the vaginal tablet, you may use either the applicator or your finger to insert the tablet. Unwrap the tablet before use. Follow the package instructions on how to fill the applicator with the vaginal tablet. Lie on your back with your knees toward your chest. Insert the tablet or the applicator into the vagina as far as it will comfortably go. Slowly press the plunger of the applicator to release the tablet.

If you have itching /burning around the outside of the vagina (vulva), apply the skin cream to that area usually once or twice a day for no more than 7 days. If you are using a product with only the vaginal cream, you may apply a small amount of the vaginal cream to the area.

Continue to use this medication every day for the full time prescribed, even if symptoms disappear after a few days or if your menstrual period starts. Stopping the medication too soon may allow the yeast infection to return.

Do not use tampons, douches, spermicides or other vaginal products while using this medication. Unscented sanitary napkins may be used for your menstrual period or to protect your clothing from leakage of the medication.

Tell your doctor if your condition does not improve after 3 days or lasts more than 7 days. Tell your doctor if your infection returns within 2 months. You may need a different or additional medication to treat your condition.

Side Effects

See also Uses section.

Vaginal/urethral burning/itching/pain, or lower abdominal cramps may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching/swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Uses section.

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal agents (such as terconazole. fluconazole ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this medication: diabetes. immune system problems (such as HIV - AIDS), frequent vaginal yeast infections (more than 3 in 6 months or 4 in 1 year).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Ask your doctor whether you can have sexual intercourse while using this product. This product may weaken rubber products (such as latex condoms. diaphragms, cervical caps) and lead to failure. This can result in pregnancy. Therefore, do not use these products during treatment with this medication. Consult your doctor about other forms of barrier protection/birth control (such as polyurethane condoms ) during this time.

Do not use this medication for self-treatment if you are pregnant. During pregnancy, this medication should be used only when clearly needed. If you are pregnant, follow your doctor's instructions on how to use the applicator to insert this medication. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may increase the risk of vaginal yeast infections include antibiotics. corticosteroids (such as prednisone ), and drugs that suppress the immune system (such as cyclosporine. methotrexate ).

Keep a list of all the products you use. Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

To help prevent vaginal yeast infections, dry the genital area thoroughly after showering, bathing, or swimming. Avoid wearing tight jeans, nylon underwear, pantyhose, a wet bathing suit, or damp/sweaty exercise clothes for long periods. Wear cotton underwear, and change your underwear daily.

If your sexual partner experiences symptoms, they should contact their doctor right away.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 36-86 degrees F (2-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

No data available at this time.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Betamet, betamet

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Buy dura-estrin 2mg

Dura-Estrin

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Estradiol injection is used to treat certain symptoms of menopause such as hot flashes and vaginal dryness, burning, or irritation. It is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism.

Some forms of estradiol injection are used in men to treat the symptoms of prostate cancer.

Estradiol injection may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Dura-Estrin (estradiol (injection))?

You should not use estradiol if you have any of the following conditions: liver disease, a bleeding disorder, unusual vaginal bleeding, a history of breast or uterine cancer, or if you have ever had a heart attack, stroke, or a blood clot.

Do not use if you are pregnant.

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Long-term use may increase your risk of breast cancer, uterine cancer, heart attack, stroke, or blood clot.

Call your doctor at once if you have any unusual vaginal bleeding while using this medicine.

What should I discuss with my health care provider before using Dura-Estrin (estradiol (injection))?

You should not use this medicine if you are allergic to estradiol, if you are pregnant, or if you have:

a bleeding or blood-clotting disorder;

a recent history of heart attack, stroke, or blood clot;

unusual vaginal bleeding that a doctor has not checked; or

any type of breast, uterine, or hormone-dependent cancer.

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

To make sure estradiol is safe for you, tell your doctor if you have:

risk factors for coronary artery disease (such as diabetes, lupus, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or if you have had a hysterectomy);

hereditary angioedema (an immune system disorder);

a history of jaundice caused by pregnancy or birth control pills;

a thyroid disorder;

epilepsy or other seizure disorder;

porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

endometriosis or uterine fibroid tumors;

gallbladder disease; or

high or low levels of calcium in your blood.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Long-term use of estradiol may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risks before using estradiol long term.

FDA pregnancy category X. Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine.

Estradiol can pass into breast milk. This medication may slow breast milk production. Tell your doctor if you are breast-feeding a baby.

How should I use Dura-Estrin (estradiol (injection))?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Estradiol is injected into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

This medicine is usually given once every 2 to 4 weeks, depending on the condition being treated. Follow your doctor's instructions.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis while using estradiol.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your estradiol injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Dura-Estrin (estradiol (injection))?

Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Dura-Estrin (estradiol (injection)) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

sudden cough, wheezing, rapid breathing, coughing up blood;

pain, swelling, warmth, or redness in one or both legs;

swelling or tenderness in your stomach;

jaundice (yellowing of the skin or eyes);

unusual vaginal bleeding;

a lump in your breast;

fluid retention (swelling, rapid weight gain);

high levels of calcium in your blood--numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes; or

dangerously high blood pressure--severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure.

Common side effects may include:

vaginal itching or discharge, changes in your menstrual periods, light vaginal bleeding or spotting;

thinning scalp hair; or

nausea, vomiting, bloating, stomach cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dura-Estrin (estradiol (injection))?

Other drugs may interact with estradiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Dura-Estrin (estradiol)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about estradiol injection.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.02. Revision Date: 2014-11-26, 12:37:33 PM.

Drug Status

User Reviews for Estradiol

Also known as: Adgyn Estro, Aerodiol, Alora, Bedol, Climara, Climaval, Climodien, Clinagen LA 40, Delestrogen, Delidose, Dep Gynogen, Depo-Estradiol, Depogen, Dermestril, Dermestril Septem, . show all 83 brand names Dioval 40, Dioval XX, Divigel, Dura-Estrin, Duragen, Elestrin, Elleste Solo, Esclim, Estra-C, Estra-V 40, Estrace, Estraderm, Estradiol G GAM, Estradiol Patch, Estradot, Estradot 100, Estradot 37.5, Estradot 50, Estradot 75, Estragyn LA 5, Estrapatch, Estrasorb, Estreva, Estro-Cyp, Estro-LA, Estro-Span 40, Estrofem, Estrogel, Estrogen Patches, Evamist, Evorel, Fematrix, Fempatch, Femring, Femsept, FemSeven, FemSeven Sequi Phase I, FemTab, Femtrace, Femtran, Gynodiol, Gynogen LA 20, Medidiol 10, Menaval-20, Menorest, Menorest Patch, Menostar, Minivelle, Nuvelle TS Phase I, Oesclim, Oestradiol Implants, Oestrodose, Oestrogel, Oestrogel Pump-Pack, Organon Oestradiol, Oromone, Primogyn Depot, Progynova, Progynova TS, Provames, Sandrena, Systen, Thais, Thaissept, Valergen, Vivelle, Vivelle-Dot, Zumenon

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Reviews for Estradiol to treat Hypoestrogenism

Estradiol Patch (estradiol): "I used the patch for night time hot flashes that wake me up every 2-3hrs. The size was great, and it stuck just fine. That's where the happy union ended. By the second day the hot flashes seemed to triple, occurring all day and all night. And the flashes were hotter! I also began to have terrible headaches that woke me up earlier than my alarm clock and hung around all day. I never have headaches so I removed the patch after only 4 days and the symptoms all went away. Now I'm back to square one better able to deal with my original symptoms knowing things could be worse. I'm going to give the name brand Vivelle dot a try and see what happens."

Exondys 51 Exondys 51 (eteplirsen) is a morpholino antisense oligomer for the treatment of Duchenne muscular.

Kyleena Kyleena (levonorgestrel-releasing intrauterine system) is a low-dose progestin-containing.

Yosprala Yosprala (aspirin and omeprazole) is a platelet aggregation inhibitor and proton pump inhibitor.

Cuvitru Cuvitru (immune globulin subcutaneous (human)) is indicated as replacement therapy in the treatment.

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Drugs. com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Sep 2nd, 2016), Cerner Multum™ (updated Sep 5th, 2016), Wolters Kluwer™ (updated Aug 8th, 2016) and others. To view content sources and attributions, please refer to our editorial policy .

We comply with the HONcode standard for trustworthy health information - verify here

Copyright © 2000-2016 Drugs. com. All rights reserved.

User Reviews for Estradiol

Also known as: Adgyn Estro, Aerodiol, Alora, Bedol, Climara, Climaval, Climodien, Clinagen LA 40, Delestrogen, Delidose, Dep Gynogen, Depo-Estradiol, Depogen, Dermestril, Dermestril Septem, . show all 83 brand names Dioval 40, Dioval XX, Divigel, Dura-Estrin, Duragen, Elestrin, Elleste Solo, Esclim, Estra-C, Estra-V 40, Estrace, Estraderm, Estradiol G GAM, Estradiol Patch, Estradot, Estradot 100, Estradot 37.5, Estradot 50, Estradot 75, Estragyn LA 5, Estrapatch, Estrasorb, Estreva, Estro-Cyp, Estro-LA, Estro-Span 40, Estrofem, Estrogel, Estrogen Patches, Evamist, Evorel, Fematrix, Fempatch, Femring, Femsept, FemSeven, FemSeven Sequi Phase I, FemTab, Femtrace, Femtran, Gynodiol, Gynogen LA 20, Medidiol 10, Menaval-20, Menorest, Menorest Patch, Menostar, Minivelle, Nuvelle TS Phase I, Oesclim, Oestradiol Implants, Oestrodose, Oestrogel, Oestrogel Pump-Pack, Organon Oestradiol, Oromone, Primogyn Depot, Progynova, Progynova TS, Provames, Sandrena, Systen, Thais, Thaissept, Valergen, Vivelle, Vivelle-Dot, Zumenon

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Primary Ovarian Failure

Summary of Estradiol reviews

Reviews for Estradiol

Climara (estradiol) for Postmenopausal Symptoms: "I am 50 years old I had a Total Abdominal Hysterectomy in April and have been suffering wicked hot sweats. I would sweat so badly that my hair, legs feet, hands and face would get wet. so disgusting. It would take me a while to dry off. I started this patch on Monday and within 12 hours, I noticed a difference and within 24 hours, the wet sweats were gone. I have to keep all the fans on in my house and have an industrial fan that I would stand in front of during my flashes. Yesterday ( day 2), I did not have to turn on a single fan and my wet sweats are completely gone. I only had a headache the first night and now I feel fantastic and normal. I still have the occasional hot flash but it is short and I don't break out in a sweat."

TrudyEllen11 September 14, 2016

0 users found this comment helpful. Did you? Yes No

Evamist (estradiol) for Postmenopausal Symptoms: "LOVE this estrogen therapy. Have tried the gels and patches and this is by far the easiest to use. It's like spraying perfume on before I walk out the door every morning, I'm only using one spray a day. Besides getting rid of my night sweats, I have more energy and feel much happier - even though I never knew how unhappy I really was until using Evamist. I got a co-pay card from my Dr and with my insurance it costs less than $25 a month. I think it's a bargain at any price! Strongly recommend you try it"

LuvmyHRT August 31, 2016

2 users found this comment helpful. Did you? Yes No

Estradiol Patch (estradiol) for Postmenopausal Symptoms: "I was caught in a vicious cycle of soaking wet hot flash after soaking wet hot flash which caused me to become agitated which caused my heart to race ALL NIGHT LONG which then caused me to be irritable and I could barely focus during the day. My doctor started me on the estradiol patch .05 mg and within a few days I felt like a new person. I now go through the entire night maybe one minor hot flash and the resulting anxiety is gone. I sleep now better than I ever have. The only side effect I have noticed is that my breasts are a little tender but not enough to make me stop. If I wind up gaining a few pounds who cares I am a human being again."

MrsSPT August 23, 2016

3 users found this comment helpful. Did you? Yes No

For Atrophic Vaginitis: "I believe I don't need to take vagifem, yes I have a prolapse, I am awaiting an operation, but the side effects have been terrible, weight loss, loss of appetite, enlarged stomach, lethargic, stomach pain. So I have decided not to continue with this medication ,"

Nanny1086 (taken for 1 to 6 months) July 21, 2016

0 users found this comment helpful. Did you? Yes No

Vivelle-Dot (estradiol) for Postmenopausal Symptoms: "I was on the Vivelle-dot for about 8 years. It took away all the unpleasantness of menopause: the insomnia, the crying, the hot flashes, the dizziness, the panic attacks. And I had absolutely no side effects. Life was great. Then, I stupidly tried to use something different in order to save money (the estradiol pill) and all the menopause horrors came back, along with new ones (nausea, acid reflux, non-stop migraines. I went back on the Vivelle-dot and felt so much better. Financially, it is a bit expensive, but I switched to the generic by Sandoz and it effects me the same as vivelle-dot. Pure bliss."

A Happy patch user (taken for 5 to 10 years) July 8, 2016

11 users found this comment helpful. Did you? Yes No

Femring (estradiol) for Postmenopausal Symptoms: "I'm at the end of my second dose of Femring after having both ovaries removed at 35. When I first went on Femring .1 mg daily it was great. I had a couple day days after initial insertion that I felt edgy emotionally - but after day 4 that leveled off. Felt much better than oral estradiol. However, around day 60 my estrogen levels started to dive and by day 80 I was back into full surgical meno. When I inserted the second ring. same as before. An initial surge of estrodiol but this time the ring started to tank around day 35. I'm on day 85 of the second ring and my meno symptoms are unbearable. For me, this is not a 90 day med. Too bad - for 1-2 months it's perfect. My insurance won't allow me to refill until day 90 - and $$$."

meno-v July 5, 2016

3 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "I tried to wan off my other not so effective hormone pills but suffered terrible back lashes. So I went to see a different and more experienced OBGYN doctor and began applying Estradiol 0.05 coupled with Progesterone 100MG treatment. Takes about 10 days to see the full positive results. I am almost one month on this treatment now, and it has stopped hot flushes, I sleep through the night, stopped horrible stress attacks, stopped near fainting temperature surge, my face skin looks tighter and younger, and strangely, makes me think about the birds and the bees. Knock on wood, I hope this medicine works for me for a long time to come. I am 64 years old, 5'3, weight 126 lbs. Use alcohol wipe and dry skin before applying patch, sticks better."

Lily323 July 4, 2016

17 users found this comment helpful. Did you? Yes No

Femring (estradiol) for Postmenopausal Symptoms: "I was placed on Femring to help with my menopausal symptoms without causing harm to my liver. I was diagnosed with a liver disorder and this has ben a blessing for me and relieved all my symptoms. It can be difficult to insert at 1st but no different than a diaphragm. I have no discomfort or pain and cannot tell it is there. The only downside is the cost."

Blondie97702 June 29, 2016

3 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "I have been on this 1mg pill a day for 1 month. I could not stand myself mood swings, irratble, my husband said I was a complete different person, just after a month. my insurance does pay. I only have to pay 8 dollors a month for it my husband said he would pay 100.00 dollors for it lol plus have lost weight on it also very happy with it saved my marriage"

Lday lucy123 (taken for less than 1 month) June 16, 2016

19 users found this comment helpful. Did you? Yes No

Estradiol Patch (estradiol) for Hypoestrogenism: "I used the patch for night time hot flashes that wake me up every 2-3hrs. The size was great, and it stuck just fine. That's where the happy union ended. By the second day the hot flashes seemed to triple, occurring all day and all night. And the flashes were hotter! I also began to have terrible headaches that woke me up earlier than my alarm clock and hung around all day. I never have headaches so I removed the patch after only 4 days and the symptoms all went away. Now I'm back to square one better able to deal with my original symptoms knowing things could be worse. I'm going to give the name brand Vivelle dot a try and see what happens."

50yr old with Hysterectomy (taken for less than 1 month) May 19, 2016

4 users found this comment helpful. Did you? Yes No

Climara (estradiol) for Postmenopausal Symptoms: "Climara Pro Estradiol Patch has reduced my hot flashes by 99%. The once a week patch takes a good three to four weeks to work. You will not find relief quickly, but once it kicks in, no hot flashes. This drug is very expensive, over $100 per month, but if you can afford it, I highly recommend it. Wipe your skin with alcohol, let dry, then apply patch--sticks better."

Elise2016 May 9, 2016

11 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "I had a full hysterectomy years ago, leaving one ovary. About a year ago I started having hot flashes, hair loss, feeling tired, etc. I went to my doctors and they ran blood work. We found out I had an underactive tyroid and was going through peri-menapause. I got on medication for my tyroid, but nothing for menapause. After a year of hot flashes and feeling like crap I went to my OBGYN yesterday. He gave me Estradiol 1mg. You have to take this with food so we went to lunch after lunch about 11:30am I took my first pill, ever. Last night I only turned the fan on once when it had been on full blast everynight for almost a year. Today, I've taken my 2nd pill ever and I haven't had not one hot flash and I feel a little more alert. "

Feelnsexi49 (taken for less than 1 month) May 7, 2016

9 users found this comment helpful. Did you? Yes No

Climara (estradiol) for Postmenopausal Symptoms: "I've only been using the .025 patch since yesterday. I have not noticed any decrease in hot flashes yet. However, I am looking forward to giving the patch a try. But, I noticed this morning that I have an allergic reaction to the adhesive. I don't want to remove it but don't want to continue to irritate my skin."

2youngforthis April 29, 2016

2 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "It didn't help with my hot flashes. I started experiencing a warm sensation, like I stood next to a heater, on my lower left outside calf all day everyday. I am getting a pain in my left arm. Dizziness and heart palpitations."

TerriBlueberry April 17, 2016

3 users found this comment helpful. Did you? Yes No

Femring (estradiol) for Postmenopausal Symptoms: ""My body does not like this ring - it is quite hard, large, and terribly uncomfortable, paid $100 for it, WITH insurance. Estradiol acetate, which is the kind of estradiol provided in this ring, has to pass through the liver, which is an inefficient way for the body to absorb." In reference to the second reviewer, Femring is a transdermal estrogen and it does not have first pass metabolism through the liver. Only oral estrogens do that. It also is not hard and if placed at the top of a normal vagina (which expands - a hysterectomy cut vagina does not do as well), you won't know it is there. I have personally used this for over 10 years and have prescribed it to 100s of patients. Over 90% loved it - except for the cost."

Anonymous (taken for 10 years or more) March 24, 2016

8 users found this comment helpful. Did you? Yes No

Divigel (estradiol) for Postmenopausal Symptoms: "I used Divigel for a few weeks. I've been having pre menopause symptoms. I had a hysterectomy but still have my ovaries. During this time I started having severe stomach pains and my ovaries hurt. The doctor performed a ultrasound. I couldn't believe the pain. The doctor told me that I may need my ovaries removed. I decided to stop using Divigel and the pain stopped. I wouldn't recommend this medication."

Beccalou05 (taken for less than 1 month) March 20, 2016

4 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "When I first started taking estradiol I was having allot of issues with hair loss, hot flashes, moodiness, vaginal dryness and bladder leakage. In short, all of the nasty side affects of menopause from my total hysterictamy. After a short time on HRT, I've noticed an improvement of all the symptoms. I normally hate taking pills and it's hard for me to stay on a regimented course of pill taking. But the positives far outweigh the negatives in this, so I have been faithful in taking my little blue pill daily. HRT isn't for everyone, but it seems to be working for me."

Fabrin March 15, 2016

21 users found this comment helpful. Did you? Yes No

Estradiol Patch (estradiol) for Postmenopausal Symptoms: "This patch had to be designed by a man. What woman would design a patch the size of a softball? I had to duck tape it on in order for it to stay on, it is not flexible ( it would not even bend in half) and what woman wants to have a big round patch showing through her clothes? You can't swim with it on or even shower because it will come off. It is hideous and degrading. Why should a woman have to be punished for something that is beyond their control? I can not say if it works or not, due to the fact that I could never get it to stay on. I took one to my doctor and asked her how I was suppose to keep it on. She was shocked at what it looked liked and put me on the pill due to the Insurance Company."

Wagon February 26, 2016

13 users found this comment helpful. Did you? Yes No

Femring (estradiol) for Postmenopausal Symptoms: "Great experience with Femring and it's the only hormone replacement that works for me. Wishing it was not so expensive."

Anonymous (taken for 5 to 10 years) February 20, 2016

7 users found this comment helpful. Did you? Yes No

Estradiol Patch (estradiol) for Postmenopausal Symptoms: "this medication saved my life. I actually like the mylan better than the vivelle as far as the way I feel, the vivelle caused sinus problems and gassy bloat, the mylan product did not for me, however the mylan product doesn't stick as well or last as long. OVERALL: I love estrogen replacement and it is a TRAGEDY that women are suffering and their docs are not offering HRT when it is now proven that HRT prolongs life and has a protective influence on heart, bones and brain. I want to tell every woman out there do not be a hero, do not suffer, and do not be afraid. estrogen is good for you and can give you your life back. why do none of the women I talk to know this? crime!!"

loribean February 19, 2016

58 users found this comment helpful. Did you? Yes No

Estradiol Patch (estradiol) for Postmenopausal Symptoms: "I have been on the estradiol patch (Vivelle) for three weeks and I feel like a new woman! Gone are the hot flashes, night sweats and brain fog. Hello energy I've missed you immensely! I also take 100 mg progesterone at bedtime. This combo is a game changer! Just wondering why I didn't pursue it sooner."

nwilling February 16, 2016

33 users found this comment helpful. Did you? Yes No

For Postmenopausal Symptoms: "Seemed to work overnight. Instant relief from mood swings, night sweats. Am using it in conjunction with progesterone at night. Sleep better and don't feel discontent with everything."

Paigepoo1 January 14, 2016

32 users found this comment helpful. Did you? Yes No

Femring (estradiol) for Postmenopausal Symptoms: "For the first 3 months things were great. On my second Femring I began to get a rash on my forehead and neck. My neck was especially red, itchy and dry. At first I thought it might be due to something else. Perhaps Eczema or psoriasis, so I was buying all kinds of creams and nothing worked. So I double checked my only prescription which is the femring and low and behold one of the possible side effects is a skin rash. It's too soon to know for sure. I hope it goes away."

Don't rash me (taken for 1 to 6 months) January 12, 2016

8 users found this comment helpful. Did you? Yes No

For Oophorectomy: "The Vivelle Dot worked beautifully. My insurance company switched me to Sandoz generic and the adhesive is awful. This brand leaves adhesive on everything - me, my underwear, my clothes. This is when it sticks properly."

Exondys 51 Exondys 51 (eteplirsen) is a morpholino antisense oligomer for the treatment of Duchenne muscular.

Kyleena Kyleena (levonorgestrel-releasing intrauterine system) is a low-dose progestin-containing.

Yosprala Yosprala (aspirin and omeprazole) is a platelet aggregation inhibitor and proton pump inhibitor.

Cuvitru Cuvitru (immune globulin subcutaneous (human)) is indicated as replacement therapy in the treatment.

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Estradiol

Estradiol is a form of estrogen. a female sex hormone that's produced by the ovaries.

Estradiol comes in an oral form, a transdermal skin patch, a vaginal ring, or as a topical gel, spray, or emulsion.

The drug is available under several brand names such as Estrace (oral pill); EvaMist (spray); Vagifem (vaginal pill); Estring, Femring (vaginal rings); Climara, Alora (skin patches); and Divigel and Estrogel (topical gels).

Estradiol is used to treat and prevent hot flushes in women experiencing menopause. Estradiol gel is also used to treat vaginal dryness, itching, and burning in menopausal women.

Estradiol is also commonly combined with progestins in various doses in oral contraceptive pills that prevent pregnancy by preventing ovulation.

The medicine may also be used to prevent osteoporosis. replace estrogen in women with ovarian failure, or as part of a cancer treatment regimen.

Estradiol is in a class of drugs called estrogen hormones. It works by replacing the estrogen that the body normally produces.

Estradiol Warnings

Estradiol can increase the risk that you will develop endometrial cancer (cancer of the lining of the uterus). If you've had a hysterectomy. you should take progestin along with estradiol to decrease this risk.

However, before taking these two medicines together, talk with your doctor about your risk for other health problems.

In one study, women who took estrogens (such as estradiol) by mouth with progestin had a higher risk of heart attacks. stroke. blood clots, breast cancer. and dementia.

Women who use topical estradiol alone or with progestin may also have a higher risk of developing these conditions.

Using topical estradiol may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks.

Before taking estradiol, tell your doctor if you have or have ever had:

A heart attack or stroke

Heart disease

Blood clots

Any type of cancer

Abnormal vaginal bleeding

High blood pressure

High cholesterol

Diabetes

Asthma

Gallbladder disease

A thyroid disorder

Epilepsy or another seizure disorder

Liver disease

Lupus

Breast lumps or abnormal mammogram results

Uterine fibroids

Yellowing of the skin or eyes (jaundice )

Migraine headaches

Endometriosis (a condition where the type of tissue that lines the uterus grows in other areas of the body, usually the abdomen or pelvis)

Low levels of calcium in your blood

Porphyria (a condition where abnormal substances build up in the blood)

Also, tell your doctor if you smoke or use tobacco products.

You should use the lowest dose of estradiol for the shortest time possible to control your symptoms.

Talk with your doctor every three to six months to determine if you should lower your dose or stop using this medicine.

You should conduct a breast self-exam every month and have a mammogram and clinical breast exam (a breast exam by a health professional) every year to help detect breast cancer.

Tell your doctor if you are having surgery or will be on bed rest while taking estradiol. Your doctor may tell you to stop taking the medication to decrease the risk of blood clots.

The topical medicine may harm other people who touch your skin. You should not let anyone else touch the skin where you applied estradiol for one hour after application.

If someone does touch the area, he or she should wash his or her hands with soap and water immediately.

Pregnancy and Estradiol

Estradiol can harm an unborn baby or cause birth defects. You should not use this medication while pregnant.

Tell your doctor right away if you become pregnant or might become pregnant while taking this drug.

Since estradiol can also pass into breast milk, talk to your doctor before breastfeeding while taking the drug.

Q: Does estradiol cause weight gain?

A: Estrogens, a group of steroid compounds, are used as part of some oral contraceptives, and in estrogen replacement therapy for postmenopausal women. Common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss. Other side effects have been reported with estrogen and/or progestin therapy including increase or decrease in weight. These are not all the possible side effects of estrogen. For a complete list, ask your doctor or pharmacist. For more detailed information, consult with your physician or pharmacist about the potential for side effects based on your specific condition and current medications.

Q: I started on estradiol about two weeks ago, and haven't had a period in about a year. I am now bleeding again. How long can I expect this to go on? It's been about 5 days now and shows no sign of stopping. I'm 54 years old.

A: While changes in your periods can be expected on estradiol, patients should contact their healthcare provider right away for any unusual vaginal bleeding. This could be a sign of a serious side effect. You may also find helpful information at http://www. everydayhealth. com/drugs/estradiol

Q: Does Estradiol cause weight gain?

A: Possibly. While weight gain is a possible side effect of any hormone, I have not heard very many woman complain about estrogens causing weight gain.

Q: How safe is estradiol? I am using it for hot flashes. What are the benefits and the risks?

A: Estrogen products are approved for the treatment of menopausal symptoms, including hot flashes. There have been several studies done by the Women's Health Initiative that have found that there is an increased risk of stroke and deep vein thrombosis (blood clots) in women 50 to 79 years of age during 7 years of treatment with 0.625mg of premarin daily. It has also been found that estrogen alone does not increase the risk of breast cancer, and in fact may decrease the risk. It is recommended to use the lowest effective dose for your symptoms for the shortest period of time. Here is a link to more information on estradiol: http://www. everydayhealth. com/drugs/estradiol Lori Poulin, PharmD

Q: I am currently taking estradiol. My hot flashes seem to be under control for now; however, my mood swings have increased. I have tried several different things, such as creams and vitamins like black cohosh. What do you recommend? My doctor seems to just increase the estradiol.

A: Estradiol is a form of estrogen that is used for a variety of conditions. Estradiol is used to relieve the symptoms of menopause, primarily hot flashes, when estrogen levels are decreasing. Mood changes are also a symptom of low estrogen and a side effect of estradiol. Most women experience some

Q: Is there a generic for Vivelle-Dot?

A: There is currently no generic equivalent available for Vivelle-Dot (estradiol transdermal system). Vivelle-Dot is a small patch containing a form of estrogen commonly used to treat ovarian disorders, infertility, abnormal bleeding, and to prevent the symptoms associated with menopause. Common side effects associated with Vivelle-Dot may include nausea, vomiting, loss of appetite, swollen breasts, acne, changes in skin color, decreased sex drive, migraine headaches, dizziness, vaginal pain, swelling of the ankles and feet, or changes in menstrual cycle. Although Vivelle-Dot does not have a generic equivalent, there is another estradiol patch available. This patch, called estradiol patch, is a generic equivalent of the Estraderm Patch. Side effects associated with Estraderm are the same as Vivelle-Dot. The Estraderm Patch, and the generic equivalent, is a larger patch then the Vivelle-Dot patch. Talk to your doctor about which treatment option best meets your needs. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jennifer Carey, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-01-08 Copyright © 2014 Everyday Health Media, LLC

Futuril, futuril

Product Description Common use Citalopram belongs to a class of selective serotonin reuptake inhibitors (SSRIs). This medication is used to treat major depression associated with mood disorders. It is also applied in the treatment of body dysmorphic disorder and anxiety.

Dosage and direction

Take Celexa by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning a proper dose for you.

Precautions Before taking Citalopram tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems. Aged people can be more sensitive to side effects of the medicine. During the pregnancy this treatment should be used only when strongly necessary. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Celexa should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Citalopram.

Possible side effect The most common side effects are quick and irregular pulse, tremor, anxiety, blurred vision, vomiting, fever, diarrhoeia, etc. A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication. Citalopram can interact with: * MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc. * Antiarrhythmic drugs: Propafenone, Quinidine, etc * Serotonin-norepinephrine reuptake inhibitors (SNRIs): Desvenlafaxine, Duloxetine, Milnacipram, Venlafaxine. * Antipsychotics (also called neuroleptics): Fluphenazine, etc. * H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc. Turn to your doctor or pharmacist for more details.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store them in the bathroom. Keep all drugs away from children and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

What is this medicine?

ESCITALOPRAM is used to treat depression and certain types of anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: bipolar disorder or a family history of bipolar disorder diabetes heart disease kidney or liver disease receiving electroconvulsive therapy seizures (convulsions) suicidal thoughts, plans, or attempt by you or a family member an unusual or allergic reaction to escitalopram, the related drug citalopram, other medicines, foods, dyes, or preservatives pregnant or trying to become pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: certain diet drugs like dexfenfluramine, fenfluramine, phentermine, sibutramine cisapride citalopram medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl nefazodone phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine procarbazine St. John's Wort venlafaxine

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like drugs carbamazepine cimetidine ketoconazole linezolid medicines for depression, anxiety, or psychotic disturbances medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin medicines that treat HIV infection or AIDS medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines used to treat tuberculosis like isoniazid, rifabutin, rifampin, rifapentine metoclopramide NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pentazocine tryptophan

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Continue taking your tablets even if you do not feel better right away. It can take 1 to 2 weeks or longer before you start to feel the effects of this medicine.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

If you have been taking this medicine regularly for some time, do not stop taking it suddenly. You must gradually reduce the dose, or your symptoms may get worse. Ask your doctor or health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible are: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion feeling faint or lightheaded, falls fast talking and excited feelings or actions that are out of control hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes unusual bleeding or bruising

Side effects that do not require medical attention usually (report to your doctor or health care professional if they continue or are bothersome): blurred vision changes in appetite change in sex drive or performance headache increased sweating nausea

This list may not describe all possible side effects.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What is this medicine?

ESCITALOPRAM is used to treat depression and certain types of anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: bipolar disorder or a family history of bipolar disorder diabetes heart disease kidney or liver disease receiving electroconvulsive therapy seizures (convulsions) suicidal thoughts, plans, or attempt by you or a family member an unusual or allergic reaction to escitalopram, the related drug citalopram, other medicines, foods, dyes, or preservatives pregnant or trying to become pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: certain diet drugs like dexfenfluramine, fenfluramine, phentermine, sibutramine cisapride citalopram medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl nefazodone phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine procarbazine St. John's Wort venlafaxine

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like drugs carbamazepine cimetidine ketoconazole linezolid medicines for depression, anxiety, or psychotic disturbances medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin medicines that treat HIV infection or AIDS medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines used to treat tuberculosis like isoniazid, rifabutin, rifampin, rifapentine metoclopramide NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pentazocine tryptophan

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Continue taking your tablets even if you do not feel better right away. It can take 1 to 2 weeks or longer before you start to feel the effects of this medicine.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

If you have been taking this medicine regularly for some time, do not stop taking it suddenly. You must gradually reduce the dose, or your symptoms may get worse. Ask your doctor or health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible are: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion feeling faint or lightheaded, falls fast talking and excited feelings or actions that are out of control hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes unusual bleeding or bruising

Side effects that do not require medical attention usually (report to your doctor or health care professional if they continue or are bothersome): blurred vision changes in appetite change in sex drive or performance headache increased sweating nausea

This list may not describe all possible side effects.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Cefuroxime - side effects, dosage, interactions, curoxime

Cefuroxime

Cefuroxime is a prescription drug available under the brand names Ceftin and Zinacef.

It's an antibiotic used to treat certain infections caused by bacteria, such as sinus infections, throat infections, Lyme disease. and gonorrhea.

Cefuroxime was originally approved by the Food and Drug Administration (FDA) under the brand name Ceftin, manufactured by GlaxoSmithKline, in 1987.

Cefuroxime Warnings

You should not take cefuroxime if you:

Are allergic to cefuroxime or any of the other ingredients contained in the drug

Are taking Theracrys (BCG live intravesical)

Talk to your doctor before taking cefuroxime if you:

Are allergic to penicillin

Are allergic to other antibiotics such as ceflacor, cefdinir, Keflex (cephalexin), or antibiotics in the cephalosporin class

Have kidney or liver problems

Have seizures

Have poor eating habits or suffer from malnutrition

Have recently had an either infection or inflammation of your intestines while or after taking antibiotics

Cefuroxime may reduce the effects of your birth control (pills, patches, or injections).

You may need to use a back-up form of birth control while taking cefuroxime.

Pregnancy and Cefuroxime

Cefuroxime falls under the FDA's Pregnancy Category B, which means that it's generally safe for your unborn baby.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Cefuroxime is found in breast milk. Tell your doctor if you are breastfeeding or plan to breastfeed before you take this medication.

Cefuroxime (Ceftin) Side Effects

Common side effects of cefuroxime include:

Nausea, vomiting, and diarrhea

Kidney problems

Diaper rash

Yeast infection

An allergic reaction

Serious side effects of cefuroxime include but are not limited to:

Life-threatening allergic reaction called anaphylaxis in which you may have trouble breathing, your throat closes up, and your skin breaks out into hives

Swelling of the face, including eyes, lips, mouth, tongue, and throat

Severe and possibly life-threatening skin-reactions like Steven-Johnsons syndrome or toxic epidermal necrolysis (TENs)

Blood disorders like low platelet count or low levels of all blood cells

Low levels of white blood cells

Seizures

A severe form of diarrhea noted by loose, watery stool and a foul smell that is much worse than normal

Cefuroxime (Ceftin) Interactions

It's always important to share with your doctor and pharmacist all of the medications you are taking.

This includes prescription and over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.

You should not take cefuroxime if you are taking Theracrys (BCG live intravesical).

Some other medications that have serious interactions with Cefuroxime include:

Acid-reflux medications like Tagamet (cimetidine), Dexilant (deslansoprazole), and Aciphex (rabeprazole)

Other acid-reflux medications like Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine)

Vivotif (live typhoid vaccine)

Aluminum hydroxide, calcium carbonate, magnesium hydroxide, sodium bicarbonate

Cellcept (mycophenolate mofetil) and Myfortic (mycophenolic acid)

Cefuroxime and Alcohol

You should avoid or limit alcohol consumption while taking cefuroxime.

Cefuroxime and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking cefuroxime.

Grapefruit juice slows down how quickly the body is able to break down cefuroxime, which could cause levels in the blood to rise dangerously high.

Cefuroxime (Ceftin) Dosage

Cefuroxime comes in 250 mg and 500 mg tablets.

Doses typically range from 250 mg twice a day to 500 mg twice a day to be taken for 5 to 10 days for most infections.

Lyme disease symptoms may be treated for up to 20 days.

For gonorrhea, your doctor may prescribe a one-time dose of 1000 mg.

It is very important to take cefuroxime exactly as your doctor prescribes and to finish taking all of the medication -- even if you start to feel better or your symptoms disappear.

Otherwise, the infection might return and become much more difficult to treat.

Cefuroxime Overdose

If you suspect an overdose of cefuroxime you should contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at (800) 222-1222.

Missed Dose of Cefuroxime

If you miss a dose of Cefuroxime, try to take it as soon as you remember.

If it's almost time for the next dose, skip the missed dose and take your next dose at the regular time.

Do not take two doses of the medication at the same time.

Drugs and medications, myonil

? Improvement of myotonic conditions caused by the following diseases :

Neck-shoulder-arm syndrome, scapulohumeral periarthritis and low back pain

? Spastic paralysis caused by the following diseases :

Cerebrovascular disorders, spastic spinal paralysis, cervical spondylosis, sequelae of surgical trauma (including cerebrospinal tumor), sequelae of trauma (spinal injury and head injury), amyotrophic lateral sclerosis, infantile cerebral palsy, spinocerebellar degeneration, spinal vascular disorder, subacute myelo-optico neuropathy (SMON) and other encephalomyelopathies

DOSAGE AND ADMINISTRATION

The usual adult dosage for oral use is 3 tablets (150 mg of eperisone hydrochloride) daily in three divided doses after meals. The dosage may be adjusted depending on the patient's age and symptoms.

(MYONAL is contraindicated in the following patients.)

Patients with a history of hypersensitivity to any ingredients of MYONAL.

1. Careful Administration (MYONAL should be administered with care in the following patients.)

(1) Patients with a history of drug hypersensitivity

(2) Patients with hepatic function disorder [MYONAL may aggravate hepatic function.]

2. Important Precautions

Weakness, light-headedness, sleepiness or other symptoms may occur. In the event of such symptoms, the dosage should be reduced or treatment discontinued. Patients should be cautioned against engaging in potentially hazardous activities requiring alertness, such as operating machinery or driving a car.

Precautions for coadministration (MYONAL should be administered with care when coadministered with the following drugs.)

[USE IN THE ELDERLY]

Since the elderly often have a physiological hypofunction, it is advisable to take measures, such as reduction in dosage under careful supervision.

[PREGNANCY AND LACTATION]

1. Use During Pregnancy MYONAL should only be used in pregnant women or women suspected of being pregnant, if the expected therapeutic benefits are evaluated to outweigh the possible risk of treatment. [The safety of MYONAL in pregnant women has not been established.] 2. Use During Lactation It is advisable to avoid the administration of MYONAL to nursing mothers. When MYONAL must be used, breast feeding should be discontinued during treatment. [It has been reported that MYONAL is excreted in breast milk in an animal study (in rats).]

Safety in children has not been established (insufficient clinical experience).

Adverse reactions were reported in 416 of 12,315 patients (3.38%).

(At the end of the reexamination period)

(1) Clinically significant adverse reactions (incidence unknown)

1) Shock and anaphylactoid reactions Since shock and anaphylactoid reactions may occur, patients should be carefully observed. In the event of symptoms such as redness, itching, urticaria, edema of the face or other parts and dyspnea etc. treatment should be discontinued and appropriate measures taken.

2) Oculo-muco-cutaneous syndrome (Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell syndrome)

Serious dermatopathy such as oculo-muco-cutaneous syndrome (Stevens-Johnson syndrome) or toxic epidermal necrolysis (Lyell syndrome) may occur. Patients should be carefully observed, treatment discontinued and appropriate measures taken, in the event of symptoms such as fever, erythema, blistering, itching, ocular congestion or stomatitis, etc.

(2) Other adverse reactions

Top ED Drugs

Cifox, cifox

Cifox - (Ciprofloxacin)

Cifox tablets and suspension contain the active ingredient ciprofloxacin, which is a type of medicine called a quinolone antibiotic. Cifox are used to treat infections caused by bacteria.

What is Cifox

Cifox works by killing the bacteria that are causing an infection. It does this by entering the bacterial cells and inhibiting a bacterial enzyme called DNA-gyrase. This enzyme is involved in replicating and repairing the genetic material (DNA) of the bacteria. If this enzyme doesn't work, the bacteria cannot reproduce or repair themselves and this kills the bacteria.

Cifox is effective against a large number of bacteria, some of which tend to be resistant to other commonly used antibiotics. It is particularly useful against a sub-group of bacteria called Gram-negative bacteria, including salmonella, shigella, campylobacter, neisseria, and pseudomonas. It is used to treat a wide range of infections, including infections of the chest. urinary tract and of the gastrointestinal system. It is also used as a single dose treatment for gonorrhoea.

To make sure the bacteria causing an infection are susceptible to Cifox your doctor may take a tissue sample, for example a swab from the throat or skin, or a urine or blood sample.

What is Cifox used for?

In adults, Cifox can be used to treat the infections below, when caused by susceptible bacteria.

Bacterial infections of the lungs and airways (respiratory tract), such as pneumonia (but not 1st line treatment of pneumococcal pneumonia ), acute bronchitis. bronchiectasis and lung infections in cystic fibrosis or chronic bronchitis .

Bacterial ear, nose and throat infections such as sinusitis. otitis media and otitis externa.

Bacterial eye infections such as bacterial conjunctivitis .

Bacterial infections of the urinary tract. such as cystitis. kidney infections (pyelonephritis), urethritis.

Bacterial infection of the prostate gland (prostatitis) or testicles (epididymitis).

Bacterial infections of the skin and soft tissue, such as infected ulcers, wounds or burns, abscesses, cellulitis, erysipelas.

Bacterial infections of bones and joints, such as osteomyelitis and septic arthritis .

Abdominal bacterial infections, such as peritonitis or abdominal abscesses.

Bacterial infections of the stomach and intestines, such as typhoid fever or infective diarrhoea .

Bacterial infections of the biliary tract or gall bladder.

Bacterial infections in the pelvis, such as pelvic inflammatory disease or infections in the uterus (endometritis ) or uterine tube (salpingitis).

Gonorrhoea.

Bacterial infection of the blood (septicaemia or blood poisoning).

Preventing infections in people having stomach or intestinal surgery or endoscopic procedures, where there is an increased risk of infection.

Preventing or treating anthrax affecting the lungs, following exposure to anthrax spores.

Before taking Cifox

Before taking ciprofloxacin make sure your doctor or pharmacist knows:

If you are pregnant, trying for a baby or breast-feeding.

If you have ever experienced tendon problems after taking any other quinolone antibiotic such as ofloxacin, levofloxacin. moxifloxacin, nalidixic acid or norfloxacin.

If you have kidney problems .

If you have epilepsy or any other condition that causes fitting.

If you have myasthenia gravis (a muscle weakening disease).

If you know you have glucose 6-phosphate dehydrogenase (G6PD) deficiency.

If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.

If you have ever had an allergic reaction to this or any other medicine.

How do I take Cifox?

The dose of this medicine and how long it needs to be taken for depends on your kidney function and the type of infection you have. Follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the packet of medicine.

Cifox is usually taken twice a day (every 12 hours).

Cifox tablets should be swallowed whole and not chewed.

Bottles of suspension should be shaken before measuring out a dose. Only use the measuring spoon provided with the suspension. You should not use a regular teaspoon or tablespoon to take the medicine, as this will not give an accurate dose.

Cifox can be taken either with or without food.

You should not take milk, yoghurt, antacids for indigestion or heartburn, or medicines containing calcium, iron, zinc, magnesium or aluminium at the same time as ciproxin. This is because these can reduce the absorption of the antibiotic from the gut.

Unless your doctor tells you otherwise, it is important that you finish the prescribed course of this antibiotic medicine, even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic.

Side effects of Cifox

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Common (affect between 1 in 10 and 1 in 100 people)

Uncommon (affect between 1 in 100 and 1 in 1000 people)

Rash.

Itching.

Loss of appetite.

Headache .

Dizziness .

Feeling weak or tired (asthenia).

Sleep disturbances.

Hyperactivity or agitation.

Taste disturbances.

Abdominal pain, flatulence (wind) or indigestion.

Vomiting.

Joint or back pain.

Fungal infections.

Rare (affect between 1 in 1000 and 1 in 10,000 people)

Disturbances in the numbers of blood cells in the blood.

Increased blood sugar levels (hyperglycaemia).

Confusion.

Anxiety .

Depression. Tell your doctor straight away if you notice any change in your mood, feelings or thoughts while taking this medicine.

Hallucinations.

Abnormal dreams.

Tremor.

Convulsions.

Pins and needles, burning or numb sensations. Tell your doctor straight away if you notice any strange sensations while taking this medicine.

Visual disturbances.

Hearing problems, including tinnitus.

Increased heart rate.

Low blood pressure or fainting.

Sweating.

Shortness of breath.

Muscle pain or cramps.

Increased sensitivity of the skin to sunlight.

Inflammation of the bowel lining.

Liver or kidney disorders. Tell your doctor if you experience any of the following symptoms while taking this medicine, as they may suggest a problem with your liver: rapidly feeling weak or unwell, unexplained itching, loss of appetite, abdominal pain, yellowing of the skin or whites of the eyes (jaundice) or unusually dark urine.

Very rare (affect less than 1 in 10,000 people)

Disturbances in smell.

Tendon disorders (see warning section above).

Psychotic reactions.

Migraine .

Inflammation of the pancreas (pancreatitis).

Severe allergic skin reactions. Consult your doctor immediately if you get a severe rash, skin peeling, or painful blisters in the mouth/nose or genitals while taking this medicine.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How to store Cifox

Keep all medicines out of the reach and sight of children.

Store in a cool, dry place, away from direct heat and light.

If you have any more questions please ask your Pharmacist.

Remember to keep all medicines out of reach of children

Please Note: We have made every effort to ensure that the content of this information sheet is correct at time of publish, but remember that information about drugs may change. This sheet does not list all the uses and side-effects associated with this drug. For full details please see the drug information leaflet which comes with your medicine. Your doctor will assess your medical circumstances and draw your attention to any information or side-effects which may be relevant in your particular case.

References:

Erythromycin stearate oral uses, side effects, interactions, pictures, warnings - dosing, etocin

erythromycin stearate

GENERIC NAME(S): ERYTHROMYCIN STEARATE

Uses

Erythromycin is used to treat a wide variety of bacterial infections. It may also be used to prevent certain bacterial infections. Erythromycin is known as a macrolide antibiotic. It works by stopping the growth of bacteria.

This antibiotic treats or prevents only bacterial infections. It will not work for viral infections (such as common cold. flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat a certain type of stomach condition involving slowed digestion (gastroparesis ).

How to use erythromycin stearate

Take this medication by mouth as directed by your doctor, usually before a meal. This medication is best absorbed when taken on an empty stomach. If nausea occurs, you may take it with food or milk.

This medication has a bitter taste if crushed. Swallow the medication whole. Do not chew or crush.

The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on age and weight .

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

If you are using this medication to treat an infection, continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.

If you are taking this medication to prevent certain bacterial infections, take it exactly as directed by your doctor. Do not stop taking the medication without your doctor's approval.

Side Effects

Nausea, vomiting. diarrhea. stomach pain /cramping, and loss of appetite may occur. Taking this medication with food may lessen these symptoms. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of liver disease (such as persistent nausea/vomiting, yellowing eyes or skin. dark urine, severe stomach/abdominal pain), unusual tiredness, muscle weakness. slurred speech, blurred vision. drooping eyelids, hearing loss .

Get medical help right away if you have any very serious side effects, including: severe dizziness. fainting. fast/irregular heartbeat .

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood /mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as azithromycin. clarithromycin ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease. liver disease, a certain type of muscle disease (myasthenia gravis ).

Erythromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using erythromycin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure. slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using erythromycin safely.

Erythromycin may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations/vaccinations while using this medication without the consent of your doctor.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Some erythromycin products may contain sodium. Ask your doctor or pharmacist for more information if you are on a salt-restricted diet or if you have a condition such as congestive heart failure that could be worsened by an increase in salt intake.

Older adults may be more sensitive to the side effects of this drug, especially hearing loss and QT prolongation (see above).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: clindamycin, digoxin.

Many drugs besides erythromycin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, cisapride, pimozide, procainamide, propafenone, quinidine, sotalol, among others.

Other medications can affect the removal of erythromycin from your body, which may affect how erythromycin works. Examples include azole antifungals (such as itraconazole, ketoconazole), certain calcium channel blockers (such as diltiazem, verapamil), certain anti-seizure medications (such as carbamazepine, phenytoin), quinupristin-dalfopristin, among others.

Erythromycin can slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include bromocriptine, colchicine, certain benzodiazepines (such as midazolam, triazolam), eletriptan, ergot alkaloids (such as ergotamine, dihydroergotamine), certain drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain "statin" drugs (such as lovastatin, simvastatin), vinblastine, among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (urine tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Kamistad gel n, kamistad

D?ch chi?t hoa cuc (1: 4-5). 185,0 mg

Ch?t b?o qu?n: Benzalkonium chloride. 1,0g

Kamistad - Gel N la thu?c d?ng gel dung cho khoang mi?ng d? di?u tr? cac ch?ng viem dau ? l?i, niem m?c mi?ng va moi. Nh? tinh ch?t gi?m dau va sat trung t?i ch?. Kamistad - Gel N cung thich h?p cho ngu?i mang rang gi? boi vao cac di?m b? chen ep d? gi?m c?m giac qua m?n c?m d?i v?i v?t l? trong giai do?n chua thich nghi. V?i tac d?ng gay te b? m?t d?c bi?t, Lidocaine hydroclorid trong Kamistad - Gel N giup gi?m dau nhanh chong va keo dai. d?c bi?t h?u ich khi viem niem m?c mi?ng va l?i. Kamistad - Gel N cung ch?a d?ch chi?t hoa cuc co tac d?ng ch?ng viem. D?ng Gel lam cho Kamistad - Gel N r?t d? lan t?a va bam dinh t?t vao niem m?c.

Cac ch?ng viem, dau ? viem m?c mi?ng va moi, k? c? trong tru?ng h?p co m?n nu?c, viem l?i (nu?u rang) va n?t n? moi do tr?i l?nh. D?i v?i ngu?i mang rang gi?, thu?c dung d? boi vao l?i, vom mi?ng va niem m?c b? kich ?ng va m?n c?m. Ngan ng?a cac tri?u ch?ng t?i ch? khi m?c rang s?a ho?c rang khon va dung trong ph?u thu?t ch?nh rang.

Kamistad « - Gel N la thu?c d?ng gel dung cho khoang mi?ng d? di?u tr? cac ch?ng viem dau ? l?i, niem m?c mi?ng va moi.

Nh? tinh ch?t gi?m dau va sat trung t?i ch?, Kamistad « - Gel N cung thich h?p cho ngu?i mang rang gi? boi vao cac di?m b? chen ep d? gi?m c?m giac qua m?n d?i v?i v?t l? trong giai do?n chua thich nghi.

V?i tac d?ng gay te b? m?t d?c bi?t, Lidocaine hydroclorid trong Kamistad « - Gel N giup gi?m dau nhanh chong va keo dai, d?c bi?t h?u ich khi viem niem m?c mi?ng va l?i. Kamistad « - Gel N cung ch?a d?ch chi?t hoa cuc co tac d?ng ch?ng viem.

D?ng gel lam cho Kamistad « - Gel N r?t d? lan t?a va bam dinh t?t vao niem m?c.

M?n c?m v?i Lidocain (hay cac thu?c gay te t?i ch? d?ng amid khac), hoa cuc ho?c b?t c? thanh ph?n nao c?a thu?c.

Common and rare side effects for xerac bp 10 topical, xerac bp

Side Effects

List Xerac Bp 10 topical side effects by likelihood and severity.

The following side effects are associated with Xerac Bp 10 topical:

Common side effects of Xerac Bp 10 topical:

Infrequent side effects of Xerac Bp 10 topical:

Skin Irritation Severe

Abnormal Peeling of Skin Less Severe

Dry Skin Less Severe

Feeling Warm Less Severe

Redness of Skin Less Severe

Stinging of Skin Less Severe

Rare side effects of Xerac Bp 10 topical:

Allergic Reaction caused by a Drug Severe

Feeling Faint Severe

Feeling of Throat Tightness Severe

Fluid Accumulation Around the Eye Severe

Hives Severe

Itching Severe

Life Threatening Allergic Reaction Severe

Puffy Face from Water Retention Severe

Rash Severe

Skin Inflammation due to a Topically Applied Medication Severe

Throat Swelling Severe

Trouble Breathing Severe

Skin Discoloration Less Severe

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Combithyrex, combithyrex

Synthroid is used for treating low thyroid hormone levels and certain types of goiters. It is also used with surgery and other medicines for managing certain types of thyroid cancer. Synthroid is a thyroid hormone. It works by replacing thyroid hormone when your body does not make enough on its own.

Use Synthroid as directed by your doctor.

Take Synthroid by mouth on an empty stomach at least one-half to one hour before breakfast.

Do not take an antacid or a product that has iron or calcium in it within 4 hours of taking Synthroid.

If the patient is a child or if you cannot swallow the tablet whole, you may crush the correct dose of the medicine. Add the crushed medicine to 1 to 2 teaspoons (5 to 10 mL) of water. Mix well. Use a spoon or dropper to give the medicine as soon as possible. Do not store the mixture for later use. Do not mix crushed tablets in soybean infant formula. Ask your pharmacist if you have any questions.

Synthroid works best if it is taken at the same time each day.

Continue to take Synthroid even if you feel well. Do not miss any dose.

It may take several weeks before you notice an improvement in your symptoms. Do not stop or change your dose of Synthroid without first checking with your doctor.

If you miss a dose of Synthroid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Synthroid.

Store Synthroid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, light, and moisture. Do not store in the bathroom. Keep Synthroid out of the reach of children and away from pets.

Active Ingredient: Levothyroxine sodium.

Do NOT use Synthroid if:

you are allergic to any ingredient in Synthroid

you have untreated adrenal gland problems or high thyroid hormone levels

you have had a recent heart attack.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Synthroid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have trouble swallowing, heart or blood vessel problems (eg, coronary artery disease), high blood pressure, blood clotting or bleeding problems, pernicious anemia, diabetes, bone problems (eg, osteoporosis), fertility problems, pituitary problems, adrenal gland problems, or other thyroid problems

if you have problems absorbing nutrition from your stomach or intestines into your body

if you had a recent surgery or have an upcoming surgery.

Some medicines may interact with Synthroid. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, nasal congestion, asthma, high blood pressure, irregular heartbeat or other heart problems, blood thinning, mental or mood problems, depression, diabetes, other thyroid problems, high cholesterol, hepatitis, weight loss, heartburn, birth control, hormone replacement therapy, growth hormone deficiency, cancer, seizures), and multivitamin products may interact with Synthroid, increasing the risk of side effects or decreasing effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthroid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

It is important to take Synthroid exactly as prescribed. Do not take more than the prescribed dose without checking with your doctor.

Tell your doctor or dentist that you take Synthroid before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Synthroid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Foods that contain soybean flour (including infant formula), cottonseed meal, walnuts, or dietary fiber may decrease the absorption of Synthroid. Tell your doctor if your diet includes any of these foods. Your doctor may need to change your dose of Synthroid.

Mild hair loss may rarely occur during the first few months of treatment with Synthroid. This is usually temporary. Contact your doctor if hair loss is severe or persistent.

Lab tests, including thyroid hormone level and growth checks, may be performed while you use Synthroid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Synthroid with caution in the elderly; they may be more sensitive to its effects, especially heart problems.

Children and teenagers may need regular growth checks while they take Synthroid.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. Your doctor may need to change your dose of Synthroid. Synthroid is found in breast milk. If you are or will be breast-feeding while you use Synthroid, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with the use of Synthroid.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); changes in appetite; changes in menstrual periods; chest pain; diarrhea; excessive sweating; fast or irregular heartbeat; fever; heat intolerance; joint pain; leg cramps; mental or mood changes (eg, anxiety, irritability, nervousness); muscle weakness; seizures; severe or persistent headache or fatigue; shortness of breath; stomach cramps; tremors; trouble sleeping; unusual weight gain or weight loss; vomiting; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Synthroid is used for treating low thyroid hormone levels and certain types of goiters. It is also used with surgery and other medicines for managing certain types of thyroid cancer. Synthroid is a thyroid hormone. It works by replacing thyroid hormone when your body does not make enough on its own.

Use Synthroid as directed by your doctor.

Take Synthroid by mouth on an empty stomach at least one-half to one hour before breakfast.

Do not take an antacid or a product that has iron or calcium in it within 4 hours of taking Synthroid.

If the patient is a child or if you cannot swallow the tablet whole, you may crush the correct dose of the medicine. Add the crushed medicine to 1 to 2 teaspoons (5 to 10 mL) of water. Mix well. Use a spoon or dropper to give the medicine as soon as possible. Do not store the mixture for later use. Do not mix crushed tablets in soybean infant formula. Ask your pharmacist if you have any questions.

Synthroid works best if it is taken at the same time each day.

Continue to take Synthroid even if you feel well. Do not miss any dose.

It may take several weeks before you notice an improvement in your symptoms. Do not stop or change your dose of Synthroid without first checking with your doctor.

If you miss a dose of Synthroid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Synthroid.

Store Synthroid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, light, and moisture. Do not store in the bathroom. Keep Synthroid out of the reach of children and away from pets.

Active Ingredient: Levothyroxine sodium.

Do NOT use Synthroid if:

you are allergic to any ingredient in Synthroid

you have untreated adrenal gland problems or high thyroid hormone levels

you have had a recent heart attack.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Synthroid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have trouble swallowing, heart or blood vessel problems (eg, coronary artery disease), high blood pressure, blood clotting or bleeding problems, pernicious anemia, diabetes, bone problems (eg, osteoporosis), fertility problems, pituitary problems, adrenal gland problems, or other thyroid problems

if you have problems absorbing nutrition from your stomach or intestines into your body

if you had a recent surgery or have an upcoming surgery.

Some medicines may interact with Synthroid. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, nasal congestion, asthma, high blood pressure, irregular heartbeat or other heart problems, blood thinning, mental or mood problems, depression, diabetes, other thyroid problems, high cholesterol, hepatitis, weight loss, heartburn, birth control, hormone replacement therapy, growth hormone deficiency, cancer, seizures), and multivitamin products may interact with Synthroid, increasing the risk of side effects or decreasing effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthroid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

It is important to take Synthroid exactly as prescribed. Do not take more than the prescribed dose without checking with your doctor.

Tell your doctor or dentist that you take Synthroid before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Synthroid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Foods that contain soybean flour (including infant formula), cottonseed meal, walnuts, or dietary fiber may decrease the absorption of Synthroid. Tell your doctor if your diet includes any of these foods. Your doctor may need to change your dose of Synthroid.

Mild hair loss may rarely occur during the first few months of treatment with Synthroid. This is usually temporary. Contact your doctor if hair loss is severe or persistent.

Lab tests, including thyroid hormone level and growth checks, may be performed while you use Synthroid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Synthroid with caution in the elderly; they may be more sensitive to its effects, especially heart problems.

Children and teenagers may need regular growth checks while they take Synthroid.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. Your doctor may need to change your dose of Synthroid. Synthroid is found in breast milk. If you are or will be breast-feeding while you use Synthroid, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with the use of Synthroid.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); changes in appetite; changes in menstrual periods; chest pain; diarrhea; excessive sweating; fast or irregular heartbeat; fever; heat intolerance; joint pain; leg cramps; mental or mood changes (eg, anxiety, irritability, nervousness); muscle weakness; seizures; severe or persistent headache or fatigue; shortness of breath; stomach cramps; tremors; trouble sleeping; unusual weight gain or weight loss; vomiting; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Synthroid is used for treating low thyroid hormone levels and certain types of goiters. It is also used with surgery and other medicines for managing certain types of thyroid cancer. Synthroid is a thyroid hormone. It works by replacing thyroid hormone when your body does not make enough on its own.

Use Synthroid as directed by your doctor.

Take Synthroid by mouth on an empty stomach at least one-half to one hour before breakfast.

Do not take an antacid or a product that has iron or calcium in it within 4 hours of taking Synthroid.

If the patient is a child or if you cannot swallow the tablet whole, you may crush the correct dose of the medicine. Add the crushed medicine to 1 to 2 teaspoons (5 to 10 mL) of water. Mix well. Use a spoon or dropper to give the medicine as soon as possible. Do not store the mixture for later use. Do not mix crushed tablets in soybean infant formula. Ask your pharmacist if you have any questions.

Synthroid works best if it is taken at the same time each day.

Continue to take Synthroid even if you feel well. Do not miss any dose.

It may take several weeks before you notice an improvement in your symptoms. Do not stop or change your dose of Synthroid without first checking with your doctor.

If you miss a dose of Synthroid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Synthroid.

Store Synthroid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, light, and moisture. Do not store in the bathroom. Keep Synthroid out of the reach of children and away from pets.

Active Ingredient: Levothyroxine sodium.

Do NOT use Synthroid if:

you are allergic to any ingredient in Synthroid

you have untreated adrenal gland problems or high thyroid hormone levels

you have had a recent heart attack.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Synthroid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have trouble swallowing, heart or blood vessel problems (eg, coronary artery disease), high blood pressure, blood clotting or bleeding problems, pernicious anemia, diabetes, bone problems (eg, osteoporosis), fertility problems, pituitary problems, adrenal gland problems, or other thyroid problems

if you have problems absorbing nutrition from your stomach or intestines into your body

if you had a recent surgery or have an upcoming surgery.

Some medicines may interact with Synthroid. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, nasal congestion, asthma, high blood pressure, irregular heartbeat or other heart problems, blood thinning, mental or mood problems, depression, diabetes, other thyroid problems, high cholesterol, hepatitis, weight loss, heartburn, birth control, hormone replacement therapy, growth hormone deficiency, cancer, seizures), and multivitamin products may interact with Synthroid, increasing the risk of side effects or decreasing effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthroid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

It is important to take Synthroid exactly as prescribed. Do not take more than the prescribed dose without checking with your doctor.

Tell your doctor or dentist that you take Synthroid before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Synthroid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Foods that contain soybean flour (including infant formula), cottonseed meal, walnuts, or dietary fiber may decrease the absorption of Synthroid. Tell your doctor if your diet includes any of these foods. Your doctor may need to change your dose of Synthroid.

Mild hair loss may rarely occur during the first few months of treatment with Synthroid. This is usually temporary. Contact your doctor if hair loss is severe or persistent.

Lab tests, including thyroid hormone level and growth checks, may be performed while you use Synthroid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Synthroid with caution in the elderly; they may be more sensitive to its effects, especially heart problems.

Children and teenagers may need regular growth checks while they take Synthroid.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. Your doctor may need to change your dose of Synthroid. Synthroid is found in breast milk. If you are or will be breast-feeding while you use Synthroid, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with the use of Synthroid.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); changes in appetite; changes in menstrual periods; chest pain; diarrhea; excessive sweating; fast or irregular heartbeat; fever; heat intolerance; joint pain; leg cramps; mental or mood changes (eg, anxiety, irritability, nervousness); muscle weakness; seizures; severe or persistent headache or fatigue; shortness of breath; stomach cramps; tremors; trouble sleeping; unusual weight gain or weight loss; vomiting; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

How to lose weight on lexapro, lozaprin

How to lose weight on Lexapro?

I was on Celexa for about 2 years and noticed about 15 pounds of weight gain. I started working out with a trainer in January and changed my eating habits as well. Still can't seem to drop a pound. Talked to my doctor and he put me on Lexapro. I have been on it for almost 2 months now and have even increased my cardio per week and eating even healthier but haven't seen a weight loss yet. Will I ever be able to lose weight while on Lexapro?

Responses (1)

Anonymous 10 Nov 2011

Hello laneyg16. Its a fair question, and I've really not an definite yes or no. I was on both celexa and lexapro and no weight gain. I now am on paxil and remeron and fighting the pounds. When it comes to psychiatric drugs, its open season so to speak. You might get responses from people saying they stopped lexapro because of the weight issue, and from others that will tell you, it wasn't an issue at all. I might say this is you haven't gained any more weight and thats a positive. Best to you,

LiverLips 10 Nov 2011

Oh no! Say it ain't so, Joe! pledge, I can see our coffee get-togethers changing to more tofu & yogourt. HA HA HA

Have a good day, everyone! I wish you the best!

Anonymous 11 Nov 2011

Good Friday morning Wendy! Hope that you're doing well. No tofu for pledge :-0) Do have yourself a good one and theres seconds on coffee and the goodies this morn, are Scottish shortbread biscuits.

Add your Comment

Further Information

Kamagra soft tabs 100 mg, sildenafil soft tablets

Sildenafil Soft (kamagra Soft By Ajanta)

Clear Sky Pharmacy serves thousands of happy customers with cheap generic prescription drugs, over-the-counter medications (OTC), and original brand medicines.

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Domina pharmaceuticals, erythrogel

Erythro - Gel Antibiotic for Skin Infections and Acne Treatment

Composition: Each 100g contains 4g erythromycin.

Indications: Erythro-Gel is a macrolide antibiotic. It interferes with bacterial protein synthesis and has a bacteriostatic or bactericidal effect. Its effect depends on its concentration and bacterial type. It has efficiency against most of gram-positive bacteria. Erythro-Gel is indicated in the treatment of impetigo, wound and burn infections, infected eczema, sycosis vulgaris and acne vulgaris and it is good tolerated by skin. It has the capability of good absorption and penetration to the follicles of sebaceous ducts. It reduces the bacterial colonies in the comedones and its metabolism products. Erythro-Gel gives good results in the case of infected acne vulgaris. It achieves the removal of pustule formation stage but it hasn’t any effect on the preformed pustules.

Usage: Erythro-Gel is for external use only. It is applied to the affected area twice daily after washing with warm water and soap and get completely dry. Acne lesions on the face, neck, and back can be treated with Erythro-Gel by using enough quantity to cover the affected area.

Side Effects: Cases of dryness, pruritis, tenderness, desquamation, erythema and feeling of burning have been reported.

Contraindications: Erythro-Gel is contraindicated in case of hypersensitivity to erythromycin.

Precautions: Erythro-Gel should be kept away from eyes, mouth and mucous membranes. The concomitant topical acne therapy should be applied with caution, because cumulative irritation effect may occur especially with the peeling and desquamating agents.

Use in Pregnancy and Lactation: Erythro-Gel could be used during pregnancy or lactation.

Resistance against Erythromycin: Resistance against erythromycin by staphylococci and streptococci is usually combined with cross-resistance against other antibiotics of macrolide type. This resistance does not appear usually during short period of therapy, but occurs on long termed therapy.

Presentation: Carton pack contains aluminum tube of 30g, with leaflet.

Dioxaflex gel, dioxaflex gel

Paraguay

DIOXAFLEX

Composici´┐Żn.

Cada comprimido recubierto contiene: diclofenac s´┐Żdico 50mg, excipientes cs.

Indicaciones.

Procesos agudos o cr´┐Żnicos que se acompa´┐Żan de dolor o inflamaci´┐Żn. Formas inflamatorias y degenerativas de las enfermedades reum´┐Żticas. Afecciones musculoesquel´┐Żticas agudas. Gota aguda. Dolor, inflamaci´┐Żn o tumefacci´┐Żn postraum´┐Żticas y posoperatorio. Cuadros dolorosos o inflamatorios ginecol´┐Żgicos (dismenorrea, anexitis).

Dosificaci´┐Żn.

Dosis inicial: 150mg de diclofenac por d´┐Ża (3 comprimidos) repartidos en dos o tres tomas. Dosis de mantenimiento: 100mg por d´┐Ża, repartidos en dos tomas.

Contraindicaciones.

Antecedentes de alergia a alguno de los componentes del producto. Ulcera gastrointestinal activa. Insuficiencia hep´┐Żtica o renal severa. Pacientes asm´┐Żticos con antecedentes de precipitaci´┐Żn de ataques agudos de asma, rinitis o urticaria por parte del ´┐Żcido acetilsalic´┐Żlico u otros f´┐Żrmacos con acci´┐Żn inhibitoria sobre la s´┐Żntesis de prostaglandinas. Al igual que todo medicamento, no se aconseja el uso en el embarazo hasta tanto estudios completos garanticen la inocuidad sobre tal estado. El diclofenac se excreta en parte en la leche materna, por lo que no se recomienda su utilizaci´┐Żn durante la lactancia.

Efectos colaterales.

A las dosis terap´┐Żuticas el producto es generalmente bien tolerado. En pacientes hipersusceptibles, pueden llegar a presentarse trastornos de car´┐Żcter leve (epigastralgia, n´┐Żuseas, diarrea, constipaci´┐Żn, cefalea, mareos) que desaparecen espont´┐Żneamente o con la supresi´┐Żn de la terapia. Al igual que con otros antiinflamatorios no esteroides puede presentarse elevaci´┐Żn transitoria de las transaminasas hep´┐Żticas. La bibliograf´┐Ża registra, a trav´┐Żs de investigaciones cl´┐Żnicas y del uso cl´┐Żnico a nivel mundial, las siguientes reacciones adversas, probablemente debidas al uso de diclofenac. Con incidencia superior al 1%. Reacciones globales: dolor abdominal o calambres, cefalea, retenci´┐Żn de l´┐Żquidos, distensi´┐Żn abdominal. Digestivas: diarrea, indigesti´┐Żn, n´┐Żuseas, constipaci´┐Żn, flatulencia, anormalidad de pruebas hep´┐Żticas, ´┐Żlcera p´┐Żptica con o sin sangrado o perforaci´┐Żn, sangrado sin ´┐Żlcera. Del SNC: v´┐Żrtigo. Dermatol´┐Żgicas: rash, prurito. Sensoriales: tinnitus. Con incidencia menor al 1%. Reacciones globales: intranquilidad, tumefacci´┐Żn de labios y lengua, fotosensibilidad, anafilaxis, reacciones anafilactoides. Cardiovasculares: hipertensi´┐Żn, insuficiencia card´┐Żaca congestiva. Digestivas: v´┐Żmitos, ictericia, melena, estomatitis aftosa, sequedad de boca y mucosas, diarrea sanguinolenta, hepatitis, necrosis hep´┐Żtica, cambios de apetito, pancreatitis con o sin hepatitis concomitante, colitis. Hemolinf´┐Żticas: descenso de la hemoglobina, leucopenia, trombocitopenia, anemia hemol´┐Żtica, anemia apl´┐Żsica, agranulocitosis, p´┐Żrpura, p´┐Żrpura al´┐Żrgica. Metab´┐Żlicas: azoemia. Del SNC: insomnio, somnolencia, depresi´┐Żn, diplop´┐Ża, ansiedad, irritabilidad, meningitis as´┐Żptica. Respiratorias: epistaxis, asma, edema lar´┐Żngeo. Dermatol´┐Żgicas: alopecia, urticaria, eccema, dermatitis, erupci´┐Żn bullosa, eritema multiforme, angioedema, s´┐Żndrome de Stevens-Johnson. Sensoriales: visi´┐Żn borrosa, trastornos del gusto, p´┐Żrdida de audici´┐Żn reversible, escotomas. Urogenitales: s´┐Żndrome nefr´┐Żtico, proteinuria, oliguria, nefritis intersticial, necrosis papilar, insuficiencia renal aguda.

Precauciones.

En tratamientos prolongados, al igual que con todo antiinflamatorio no esteroide, debe realizarse el control peri´┐Żdico de las funciones hepatorrenales y hem´┐Żticas. En pacientes con insuficiencia card´┐Żaca, cirr´┐Żticos, nefr´┐Żticos y especialmente en los ancianos (al comienzo del tratamiento) se recomienda vigilar el volumen de la diuresis y la funci´┐Żn renal. En pacientes con cuadros de insuficiencia card´┐Żaca o hipertensi´┐Żn, el medicamento debe ser administrado con precauci´┐Żn por su contenido en sodio. En tales enfermos, cuando se obtengan resultados terap´┐Żuticos beneficiosos que justifiquen el empleo prolongado, deben efectuarse controles constantes de la tensi´┐Żn arterial. Debe evitarse el uso en pacientes con porfiria hep´┐Żtica. La aparici´┐Żn de efectos adversos es m´┐Żs frecuente en pacientes a´┐Żosos. Cuando aparezcan los siguientes s´┐Żntomas, debe avisarse inmediatamente al m´┐Żdico: n´┐Żuseas y v´┐Żmitos, fatiga, prurito y coloraci´┐Żn amarilla de la piel y mucosas. El m´┐Żdico y el paciente deben permanecer en alerta con respecto a la aparici´┐Żn de ´┐Żlcera o sangrado en enfermos tratados cr´┐Żnicamente, aun en ausencia de s´┐Żntomas gastrointestinales previos. Uso en pediatr´┐Ża: no se recomienda el uso del producto en ni´┐Żos, mientras no se determine su utilidad y dosificaci´┐Żn en pediatr´┐Ża.

Interacciones.

El diclofenac podr´┐Ża aumentar el efecto de los anticoagulantes orales y la heparina. Puede aumentar la toxicidad hematol´┐Żgica del metotrexato. Puede disminuir la actividad de los diur´┐Żticos y aumentar el riesgo de nefrotoxicidad. Puede aumentar el efecto hipoglucemiante de las sulfonilureas, la concentraci´┐Żn plasm´┐Żtica de digoxina o litio, la nefrotoxicidad de la ciclosporina. El uso simult´┐Żneo con ´┐Żcido acetilsalic´┐Żlico reduce rec´┐Żprocamente la biodisponibilidad.

Conservaci´┐Żn.

Conservar al abrigo del calor (no mayor de 30´┐ŻC) y de la humedad excesiva.

Sobredosificaci´┐Żn.

No se ha detectado una sintomatolog´┐Ża caracter´┐Żstica para este evento. La bibliograf´┐Ża registra, por ejemplo un caso fatal ante la ingesta de 5g de diclofenac, y s´┐Żlo v´┐Żmitos y somnolencia o ausencia de s´┐Żntomas ante la ingesti´┐Żn de 2,5 a 4g. En caso de sobredosis, se recomienda la consulta a un centro toxicol´┐Żgico.

Presentaci´┐Żn.

Env. con 20 comp. rec. de 50mg.

DIOXAFLEX

DIOXAFLEX

Cada ampolla contiene: diclofenac s´┐Żdico 75mg, excipientes cs.

Dosificaci´┐Żn.

Como posolog´┐Ża media de orientaci´┐Żn en adultos, se aconseja: 1 o 2 ampollas diarias por v´┐Ża intramuscular profunda exclusivamente, pasando a la v´┐Ża oral en cuanto la mejor´┐Ża del cuadro lo permita.

Contraindicaciones.

Antecedentes de alergia a alguno de los componentes del producto. Ulcera gastrointestinal activa. Insuficiencia hep´┐Żtica o renal severa. Pacientes asm´┐Żticos con antecedentes de precipitaci´┐Żn de ataques agudos de asma, rinitis o urticaria por parte del ´┐Żcido acetilsalic´┐Żlico u otros f´┐Żrmacos con acci´┐Żn inhibitoria sobre la s´┐Żntesis de prostaglandinas. Al igual que todo medicamento, no se aconseja el uso en embarazo y lactancia hasta tanto estudios completos garanticen la inocuidad sobre tales estados. Tampoco se recomienda el uso en ni´┐Żos, mientras no se determine su utilidad y dosificaci´┐Żn en pediatr´┐Ża.

Efectos colaterales.

A las dosis terap´┐Żuticas el producto es generalmente bien tolerado. En pacientes hipersusceptibles, pueden llegar a presentarse trastornos de car´┐Żcter leve (epigastralgia, n´┐Żuseas, diarrea, constipaci´┐Żn, cefalea, mareos) que desaparecen espont´┐Żneamente o con la supresi´┐Żn de la terapia. Al igual que con otros antiinflamatorios no esteroides puede presentarse elevaci´┐Żn transitoria de las transaminasas hep´┐Żticas. Se han descripto raros casos de edemas perif´┐Żricos, reacciones cut´┐Żneas (rash, eccema, prurito) y trastornos gastrointestinales severos (´┐Żlcera p´┐Żptica con o sin sangrado o perforaci´┐Żn, o sangrado sin ulceraciones). La bibliograf´┐Ża registra la presentaci´┐Żn excepcional de trastornos a nivel del SNC (insomnio, irritabilidad, astenia), hep´┐Żticos (hepatitis fulminante), renales (insuficiencia por reducci´┐Żn del flujo), hematol´┐Żgicos (leucopenia, trombocitopenia, anemia apl´┐Żsica), reacciones de hipersensibilidad (broncospasmo, reacciones anafilactoides). Se han descripto efectos indeseables locales en el sitio de aplicaci´┐Żn, tales como dolor postinyecci´┐Żn, induraci´┐Żn y, excepcionalmente, abscedaci´┐Żn y necrosis (estos ´┐Żltimos sobre todo en sujetos diab´┐Żticos de edad avanzada).

Precauciones.

En tratamientos prolongados, al igual que con todo antiinflamatorio no esteroide, debe realizarse el control peri´┐Żdico de las funciones hepatorrenales y hem´┐Żticas. En pacientes con insuficiencia card´┐Żaca, cirr´┐Żticos, nefr´┐Żticos y especialmente en los ancianos (al comienzo del tratamiento) se recomienda vigilar el volumen de la diuresis y la funci´┐Żn renal. En pacientes con cuadros de insuficiencia card´┐Żaca o hipertensi´┐Żn, el medicamento debe ser administrado con precauci´┐Żn por su contenido en sodio. En tales enfermos, cuando se obtengan resultados terap´┐Żuticos beneficiosos que justifiquen el empleo prolongado, deben efectuarse controles constantes de la tensi´┐Żn arterial. Debe evitarse el uso en pacientes con porfiria hep´┐Żtica. La aparici´┐Żn de efectos adversos es m´┐Żs frecuente en pacientes a´┐Żosos. Cuando aparezcan los siguientes s´┐Żntomas debe avisarse inmediatamente al m´┐Żdico: n´┐Żuseas y v´┐Żmitos, fatiga, prurito y coloraci´┐Żn amarilla de la piel y mucosas.

Interacciones.

El diclofenac podr´┐Ża aumentar el efecto de los anticoagulantes orales y la heparina. Puede aumentar la toxicidad hematol´┐Żgica del metotrexato. Puede disminuir la actividad de los diur´┐Żticos y aumentar el riesgo de toxicidad. Puede aumentar el efecto hipoglucemiante de las sulfonilureas, la concentraci´┐Żn plasm´┐Żtica de digoxina o litio y la nefrotoxicidad de ciclosporina. El uso simult´┐Żneo con ´┐Żcido acetilsalic´┐Żlico reduce rec´┐Żprocamente la biodisponibilidad.

Presentaci´┐Żn.

Env. con 5 amp. de 75mg.

DIOXAFLEX

BAGO

Parche

Analg´┐Żsico. Antiinflamatorio. Antiedematoso.

Composici´┐Żn.

Cada parche de 10 x 14cm contiene: diclofenac s´┐Żdico (como diclofenac epolamina) 140mg; excipientes: gelatina, povidona, soluci´┐Żn de D-sorbitol al 70%, caol´┐Żn, di´┐Żxido de titanio, propilenglicol, metilparabeno, edetato dis´┐Żdico, ´┐Żcido tart´┐Żrico, aminoacetato de dihidroxialuminio, carboximetilcelulosa s´┐Żdica, poliacrilato s´┐Żdico, 1,3-butilenglicol, polisorbato 80, fragancia Dalin PH, agua purificada 4161, pa´┐Żo de poli´┐Żster destramado, pel´┐Żcula de polipropileno, csp 14g.

Indicaciones.

Tratamiento local del dolor, la inflamaci´┐Żn y la tumefacci´┐Żn, consecutivos a entorsis, luxaciones, contusiones, distensiones musculares, artrosis, etc.

Dosificaci´┐Żn.

La dosificaci´┐Żn se ajustar´┐Ż seg´┐Żn criterio m´┐Żdico al cuadro cl´┐Żnico del paciente. Como posolog´┐Ża media de orientaci´┐Żn, se aconseja: aplicar un parche autoadhesivo dos veces por d´┐Ża (cada 12 horas) sobre la zona afectada. Forma de administraci´┐Żn: 1- cortar el sobre que contiene los parches por el sitio indicado; 2- retirar un parche y volver a cerrar cuidadosamente el sobre; 3- quitar la hoja pl´┐Żstica que protege la superficie adhesiva del parche; 4- aplicar el parche sobre la parte afectada. No modificar la frecuencia y modo de aplicaci´┐Żn del medicamento se´┐Żalados por el m´┐Żdico. En casos de excesiva movilidad o transpiraci´┐Żn abundante, se aconseja fijar el parche con tela adhesiva o con una muslera, rodillera o tobillera. Si se desea higienizar la zona o tomar un ba´┐Żo durante el per´┐Żodo de aplicaci´┐Żn, se debe retirar el parche y volverlo a colocar una vez cumplida dicha tarea. Consultar al m´┐Żdico ante cualquier duda.

Contraindicaciones.

Aplicaci´┐Żn sobre heridas abiertas (excoriaciones, cortaduras, etc.). Hipersensibilidad al principio activo o a alguno de los componentes. Hipersensibilidad a otros medicamentos antiinflamatorios no esteroides; en raz´┐Żn de la falta de experiencia con el producto durante el embarazo y la lactancia, se contraindica su uso en estos estados.

Efectos colaterales.

En pacientes particularmente sensibles puede aparecer a veces prurito, rubefacci´┐Żn o sensaci´┐Żn de quemadura y, raramente, erupci´┐Żn cut´┐Żnea o reacciones de fotosensibilidad.

Precauciones.

No obstante tratarse de un medicamento de aplicaci´┐Żn local, no pueden excluirse reacciones generales de hipersensibilidad comunes a cualquier antiinflamatorio: asma, urticaria, hinchaz´┐Żn de la cara y la cavidad bucal. En pacientes que padecen asma o urticaria cr´┐Żnica o en al´┐Żrgicos a la aspirina, el riesgo es mayor. Debe evitarse que el producto entre en contacto con los ojos y las mucosas. Antes de indicar el medicamento, se establecer´┐Ż si el paciente ha experimentado reacciones al´┐Żrgicas durante la utilizaci´┐Żn previa de productos semejantes (pomadas antirreum´┐Żticas), si sufre otras enfermedades, si es al´┐Żrgico o est´┐Ż tomando otros medicamentos (incluso automedicados).

Interacciones.

No se han detectado hasta el momento.

Antagonismos y antidotismos.

No se han detectado hasta el momento.

Conservaci´┐Żn.

Conservar a temperaturas menores de 25´┐ŻC. En su acondicionamiento original, los parches no deben ser utilizados m´┐Żs all´┐Ż de la fecha de vencimiento impresa en el envase. Despu´┐Żs de la primera apertura del sobre, los parches contenidos pueden ser utilizados en un plazo de tres meses.

Presentaci´┐Żn.

Env. con 2 parches.

DIOXAFLEX

BAGO

75mg

Antiinflamatorio. Analg´┐Żsico. Antirreum´┐Żtico.

Composici´┐Żn.

Cada comprimido recubierto de liberaci´┐Żn prolongada contiene: diclofenac s´┐Żdico 75mg, excipientes cs.

Indicaciones.

Formas inflamatorias y degenerativas de las enfermedades reum´┐Żticas. Afecciones musculoesquel´┐Żticas agudas. Gota aguda. Inflamaci´┐Żn y tumefacci´┐Żn postraum´┐Żtica y posoperatoria. Cuadros dolorosos o inflamatorios ginecol´┐Żgicos (dismenorrea).

Dosificaci´┐Żn.

Adultos: 1 comprimido por d´┐Ża en los casos leves o en tratamientos prolongados. El horario de administraci´┐Żn se adaptar´┐Ż de acuerdo al momento en que la sintomatolog´┐Ża es m´┐Żs evidente. De ser necesario esta dosis puede aumentarse a 2 comprimidos por d´┐Ża (1 cada 12 horas). Los comprimidos deben ingerirse enteros, sin masticar, con un poco de l´┐Żquido, preferentemente con las comidas.

Contraindicaciones.

Antecedentes de alergia a alguno de los componentes del producto. Ulcera gastrointestinal activa. Insuficiencia hep´┐Żtica o renal severa. Pacientes asm´┐Żticos con antecedentes de precipitaci´┐Żn de ataques agudos de asma, rinitis o urticaria por parte del ´┐Żcido acetilsalic´┐Żlico u otros f´┐Żrmacos con acci´┐Żn inhibitoria sobre la s´┐Żntesis de prostaglandinas. Al igual que todo medicamento, no se recomienda el uso durante el embarazo y la lactancia hasta tanto estudios completos garanticen la inocuidad en tales estados. Tampoco se recomienda el uso en ni´┐Żos mientras no se determine su utilidad y dosificaci´┐Żn en pediatr´┐Ża.

Efectos colaterales.

A las dosis terap´┐Żuticas el producto es generalmente bien tolerado. En pacientes hipersusceptibles pueden llegar a presentarse trastornos de car´┐Żcter leve (epigastralgia, n´┐Żuseas, diarrea, constipaci´┐Żn, cefalea, mareos) que desaparecen espont´┐Żneamente o con la supresi´┐Żn de la terapia. Al igual que con otros antiinflamatorios no esteroides puede presentarse elevaci´┐Żn transitoria de las transaminasas hep´┐Żticas. Se han descripto raros casos de edemas perif´┐Żricos, reacciones cut´┐Żneas (rash, eccema, prurito) y trastornos gastrointestinales severos (´┐Żlcera p´┐Żptica con o sin sangrado o perforaci´┐Żn, o sangrado sin ulceraciones). La bibliograf´┐Ża registra la presentaci´┐Żn excepcional de trastornos a nivel del SNC (insomnio, irritabilidad, astenia), hep´┐Żticos (hepatitis fulminante), renales (insuficiencia por reducci´┐Żn de flujo), hematol´┐Żgicos (leucopenia, trombocitopenia, anemia apl´┐Żsica), reacciones de hipersensibilidad (broncospasmo, reacciones anafilactoides).

Precauciones.

En tratamientos prolongados, al igual que todo antiinflamatorio no esteroide, debe realizarse un control peri´┐Żdico de las funciones hepatorrenales y hem´┐Żticas. No utilizar en ni´┐Żos menores de 14 a´┐Żos. Al igual que todo medicamento, DIOXAFLEX 75mg debe ser mantenido fuera del alcance de los ni´┐Żos.

Interacciones.

El diclofenac podr´┐Ża aumentar el efecto de los anticoagulantes orales y la heparina. Puede aumentar la toxicidad hematol´┐Żgica del metotrexato. Puede disminuir la actividad de los diur´┐Żticos. Puede aumentar el efecto hipoglucemiante de las sulfonilureas, la concentraci´┐Żn plasm´┐Żtica de digoxina o litio y la nefrotoxicidad de la ciclosporina. El uso simult´┐Żneo con ´┐Żcido acetilsalic´┐Żlico reduce rec´┐Żprocamente la biodisponibilidad.

Conservaci´┐Żn.

Conservar al abrigo del calor (no mayor de 30´┐ŻC) y de la humedad excesiva.

Sobredosificaci´┐Żn.

No se ha detectado una sintomatolog´┐Ża caracter´┐Żstica para este evento. La bibliograf´┐Ża registra por ejemplo: insuficiencia renal aguda, v´┐Żmitos y somnolencia o ausencia de s´┐Żntomas ante la ingesti´┐Żn de 2 o 2,5g de diclofenac. En caso de sobredosis, adem´┐Żs de las medidas de control general, en el momento agudo puede ser ´┐Żtil el vaciado g´┐Żstrico mediante inducci´┐Żn del v´┐Żmito o lavado. Puede ser te´┐Żricamente ´┐Żtil la diuresis forzada, dado que el diclofenac se excreta por orina. El uso de carb´┐Żn activado puede contribuir a reducir la absorci´┐Żn del f´┐Żrmaco.

Presentaci´┐Żn.

Env. con 15 comp. rec. de lib. prolongada de 75mg.